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Development and validation of a biomarker-based long-term support program for smoking cessation during pregnancy/lactation period

Research Project

Project/Area Number 23593359
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Lifelong developmental nursing
Research InstitutionInternational University of Health and Welfare (2013-2014)
Fukuoka University (2011-2012)

Principal Investigator

TSUKAHARA HITOMI  国際医療福祉大学, 保健医療学部, 教授 (20555403)

Co-Investigator(Kenkyū-buntansha) NAKASIMA Emiko  国際医療福祉大学, 保健医療学部, 教授 (30461536)
SAKUMA Yoshiko  福岡大学, 医学部, 准教授 (80554758)
嶋松 陽子  活水女子大学, 看護学部, 教授 (80270099)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords禁煙 / 妊産婦 / コチニン / 受動喫煙 / バイオマーカー / 能動喫煙 / 喫煙 / 精密酸化脂質物質 / 酸化ストレス物質
Outline of Final Research Achievements

Smoking cessation support for women in their 20s and 30s is crucial for the optimal development of the next generation. The present study aimed to develop and validate biomarker indices of the ill effects of smoking to motivate expectant and nursing mothers to stop smoking.
Exploratory study was conducted to evaluate the active/passive smoking-derived cotinine levels and breath CO concentration in maternal blood, urine, and umbilical cord blood between pregnancy period and one-month postpartum checkup. The conditions of labor and delivery were also explored. On the basis of the obtained results, personalized biomarker change indices were created because of the individual differences in the smoking status and cotinine levels in maternal blood, urine, and umbilical cord blood. Future studies should aim to use and validate the effects of these biomarkers for group guidance of women before pregnancy and for individual guidance of smokers.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (5 results)

All 2015 2014 2012 2011 Other

All Presentation (4 results) Book (1 results)

  • [Presentation] 母体の能動喫煙状況とニコチン代謝産物(コチニン)濃度の実態2014

    • Author(s)
      塚原ひとみ 佐久間良子 中嶋恵美子
    • Organizer
      第34回日本看護科学学会学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2014-11-29 – 2014-11-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 禁煙補助薬比較試験における禁煙成功・不成功事例の背景要因2012

    • Author(s)
      塚原ひとみ
    • Organizer
      第69回日本循環器心身医学会総会
    • Place of Presentation
      福岡大学
    • Related Report
      2012 Research-status Report
  • [Presentation] 禁煙補助薬バレニクリンとニコチンパチ比較試験における胃腸障害・禁煙効果の実感と体重増加との関連2011

    • Author(s)
      塚原ひとみ  中嶋恵美子 佐久間良子 嶋松陽子
    • Organizer
      第31回日本看護科学学会
    • Place of Presentation
      高知
    • Related Report
      2011 Research-status Report
  • [Presentation] 母体の能動・受動喫煙による母体と臍帯血中のコチニン濃度の実態~妊娠中・分娩時の状況分析~

    • Author(s)
      塚原ひとみ 佐久間良子 中嶋恵美子
    • Organizer
      第33回日本看護科学学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Book] バイオマーカーを指標とした妊娠期・授乳期の長期的禁煙支援プログラムの開発と検証報告書2015

    • Author(s)
      塚原ひとみ
    • Total Pages
      80
    • Publisher
      博多印刷
    • Related Report
      2014 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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