The influence on bone marrow cells of the indoor environment chemicals: Analysis of dendritic cell differentiation and the Treg induction
| Project/Area Number |
23601027
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Children studies (Studies of environment on children)
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Yasuhiro 産業医科大学, 医学部, 准教授 (10309958)
KURODA Etsushi 産業医科大学, 医学部, 講師 (10299604)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 室内環境化学物質 / 制御性T細部 / 骨髄由来細胞 / STAT5 / 胎児期暴露 / 転写因子 / 胸腺細胞 / ホルムアルデヒド / 骨髄細胞 / 胎児期曝露 / 次世代影響 / 樹状細胞 / Treg |
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| Research Abstract |
As it has been reported that exposure of a wide variety of chemical substances to the child was increased, we investigated the effect of a substance chemical, such as formaldehyde and toluene, which is suspected in particular the effect of chemical prenatal period. From consideration of the exposure model mice, thymocytes immediately prepared from exposed mice after birth. Additionally, bone marrow derived cells were also highly activated.
Thus, the low concentration chemical prenatal exposure affected cellular events on the molecular level.
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Report
(4 results)
Research Products
(9 results)
