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The influence on bone marrow cells of the indoor environment chemicals: Analysis of dendritic cell differentiation and the Treg induction

Research Project

Project/Area Number 23601027
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Children studies (Studies of environment on children)
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

SUGIURA Tsutomu  産業医科大学, 医学部, 非常勤講師 (40131924)

Co-Investigator(Kenkyū-buntansha) YOSHIDA Yasuhiro  産業医科大学, 医学部, 准教授 (10309958)
KURODA Etsushi  産業医科大学, 医学部, 講師 (10299604)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords室内環境化学物質 / 制御性T細部 / 骨髄由来細胞 / STAT5 / 胎児期暴露 / 転写因子 / 胸腺細胞 / ホルムアルデヒド / 骨髄細胞 / 胎児期曝露 / 次世代影響 / 樹状細胞 / Treg
Research Abstract

As it has been reported that exposure of a wide variety of chemical substances to the child was increased, we investigated the effect of a substance chemical, such as formaldehyde and toluene, which is suspected in particular the effect of chemical prenatal period. From consideration of the exposure model mice, thymocytes immediately prepared from exposed mice after birth. Additionally, bone marrow derived cells were also highly activated.
Thus, the low concentration chemical prenatal exposure affected cellular events on the molecular level.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (9 results)

All 2013 2012 2011 Other

All Journal Article (1 results) Presentation (8 results) (of which Invited: 4 results)

  • [Journal Article] Developmental stage-specific changes in immunological biomarkers in male C3H/HeN mice after early life toluene exposure2012

    • Author(s)
      Tin-Tin Win-Shwe, Naoki Kunugita, Daisuke Nakajima, Yasuhiro Yoshida, Hidekazu Fujimaki.
    • Journal Title

      Toxicology Letters

      Volume: 208 Issue: 2 Pages: 133-141

    • DOI

      10.1016/j.toxlet.2011.10.015

    • Related Report
      2013 Final Research Report
  • [Presentation] 室内環境汚染物質2-エチルヘキサノールの免疫細胞機能に対する影響2013

    • Author(s)
      森田健太郎,吉田安宏ら
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Year and Date
      2013-12-04
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] The indoor air pollutant 2-ethyl-hexanol affects immune cells2012

    • Author(s)
      森田健太郎,吉田安宏ら.
    • Organizer
      第42回日本免疫学会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2012-10-20
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 化学物質暴露による特異抗体の検出に関する研究2012

    • Author(s)
      余旭勝,吉田安宏ら.
    • Organizer
      第30回産業医科大学学会
    • Place of Presentation
      ラマツィーニホール(北九州)
    • Year and Date
      2012-10-20
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 化学物質曝露による特異的抗体の検出に関する研究2012

    • Author(s)
      余旭勝、吉田安宏ら
    • Organizer
      第30回産業医科大学学大会
    • Place of Presentation
      ラマツィーニホール(北九州)
    • Related Report
      2012 Research-status Report
  • [Presentation] Intratracheal administration of Asian sand dust induces autophagic and apoptotic phenomena in splenocytes2011

    • Author(s)
      Song, Y., Yoshida, Y.
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2011-12-08
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Intratracheal administration of Asian sand dust induces autophagic and apoptotic phenomena in splenocytes.2011

    • Author(s)
      Song, Y., Yoshida, Y.
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2011 Research-status Report
  • [Presentation] 室内空気汚染物質2-エチルヘキサノールの免疫機能に対する影響

    • Author(s)
      森田 健太郎, 宋 媛, 中西 司, 吉田安宏
    • Organizer
      第36回日本分子生物学会総会
    • Place of Presentation
      神戸(国際会議場)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The indoor air pollutant 2-ethyl-hexanol affects immune cells

    • Author(s)
      Morita Kentaro, Song Yuan, Nakanishi Tsukasa, Yoshida Yasuhiro.
    • Organizer
      第42回日本免疫学会総会
    • Place of Presentation
      千葉(幕張メッセ)
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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