Development of quantitative functional evaluation system for small animals using malti-modal imaging system

• Project/Area Number: 23602009
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical Physics/Radiological Technology
• Research Institution: Fukushima Medical University (2013); The University of Tokushima (2011-2012)
• Principal Investigator: KUBO Hitoshi 福島県立医科大学, 公私立大学の部局等, 准教授 (00325292)
• Co-Investigator(Kenkyū-buntansha): HARADA Masafumi 徳島大学, 大学院ヘルスバイオサイエンス, 教授 (20228654)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 分子イメージング / 陽電子放出断層撮影 / 光イメージング / 無麻酔 / 小動物イメージング / 小動物 / マウス / 無麻酔測定

Research Abstract

Mouse fixation device for multi-modal imaging with no anesthesia was developed in this study. Fixation device was made with fixation plate using acrylic board and fixation folder using 50ml centrifuge tube. The changes of kinetics of glucose analogue tracer in in vivo with and without anesthesia were evaluated using fluorescent imaging (FLI) and positron emission tomography (PET) with this fixation device.
The uptake of the tracer in the brain measured with anesthesia was decreased in compared with non anesthesia and the decrease rate in FLI was higher than that in PET. It was thought that the reasons of it were the changes of cerebral blood flow and the differences of the tracers. It should be attention that a change may be occurred if the imaging device is changed for the imaging without anesthesia.

Research Products

• [Journal Article] The impact of self-shielded cyclotron operation on small-animal PET/CT equipment installed nearby, on the floor just above (2014)
  • Author(s): Kubo H, Otani T, Otsuka H, Harada M.
  • Journal Title: Journal of Medical Investiagtion Volume: 61(1.2) Pages: 46-52
  • NAID: 130004822716
• [Journal Article] The impact of self-shielded cyclotron operation on small animal PEt/CT equipment installed neaby, on the floor just above. (2014)
  • Author(s): Hitoshi Kubo, Tamaki Otani, Hideki Otsuka, Masafumi Harada
  • Journal Title: The Journal of Medical Investigation Volume: Vol. 61 No. 1, 2 Pages: 46-52
  • Peer Reviewed