Fundamental and clinical studies on angiogenesis by vibration therapy: Why does the comfortable vibration promote wound healing?

• Project/Area Number: 23612001
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Mechanobiology
• Research Institution: The University of Tokyo
• Principal Investigator: NAGASE Takashi 東京大学, 医学(系)研究科(研究院), 客員研究員 (00359613)
• Co-Investigator(Kenkyū-buntansha): NAKAGAMI Gojiro 東京大学, 大学院医学系研究科, 講師 (70547827) ; MINEMATSU Takeo 東京大学, 大学院医学系研究科, 講師 (00398752) ; MORI Taketoshi 東京大学, 大学院医学系研究科, 准教授 (20272586) ; AKASE Tomoko 横浜市立大学, 医学部, 教授 (50276630)
• Co-Investigator(Renkei-kenkyūsha): SANADA Hiromi 東京大学, 大学院医学系研究科, 教授 (50143920)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
• Keywords: 創傷看護学 / 振動 / 褥瘡 / 糖尿病性足潰瘍 / 低酸素 / タンパク質分解酵素 / 血管新生 / 創傷治癒 / Deep Tissue Injury / 国際情報交換 / インドネシア

Research Abstract

Our research group have developed a novel wound healing vibrator. In this study, we investigated the effects and its molecular mechanisms of vibrator on the deep tissue injuries (DTIs) and diabetic foot ulcers, for which the effective intervention have not been established.
We investigated the effects of vibration on DTI in the animal study, in which we used a unique model rat for DTI deterioration. We revealed that vibration improved the tissue hypoxia and remarkably attenuated the ulceration of wounds.
We conducted a randomized control study in two hospitals in Indonesia (international collaborative research) to reveal the promoting effect of vibration on diabetic foot ulcer. We found the significant decreases of wound area reduction and healing period in the vibration group.

Research Products

• [Journal Article] Establishment of a novel rat model for deep tissue injury deterioration. (2015)
  • Author(s): Sari Y, Minematsu T, Huang L, Noguchi H, Mori T, Nakagami G, Nagase T, Oe M, Sugama J, Yoshimura K, Sanada H.
  • Journal Title: International Wound Journal Volume: 12 Issue: 2 Pages: 202-209
  • DOI: 10.1111/iwj.12082
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Establishment of a Novel Rat Model for Deep Tissue Injury Deterioration. (2013)
  • Author(s): Sari Y
  • Journal Title: International Wound Journal Volume: In press
  • Peer Reviewed
• [Presentation] New insight in etiology of deep tissue injury (2012)
  • Author(s): Nagase T, Sanada H, Nakagami G, Minematsu T, Sari Y, Sugama J
  • Organizer: 4th Congress of the World Union of Wound Healing Societies
  • Place of Presentation: Yokohama (Japan)
• [Presentation] Vibration attenuates the deterioration of deep tissue injury (2012)
  • Author(s): Sari Y, Minematsu T, Nakagami G, Nagase T, Oe M, Mori T, Sugama J, Sanada H
  • Organizer: 4th Congress of the World Union of Wound Healing Societies
  • Place of Presentation: Yokohama (Japan)
• [Presentation] Vibration attenuates the deterioration of deep tissue injury. (2012)
  • Author(s): Sari Y
  • Organizer: 4th Congress of the World Union of Wound Healing Societies.
  • Place of Presentation: 神奈川県（パシフィコ横浜）
• [Presentation] New insight in etiology of deep tissue injury. (2012)
  • Author(s): Nagase T
  • Organizer: 4th Congress of the World Union of Wound Healing Societies.
  • Place of Presentation: 神奈川県（パシフィコ横浜）
• [Presentation] Establishment of novel model for deterioration of deep tissue injury in rat (2011)
  • Author(s): Sari Y, Minematsu T, Nakagami G, Akase T, Nagase T, Oe M, Mori T, Sugama J, Sanada H
  • Organizer: 第20回日本創傷・オストミー・失禁管理学会学術集会
  • Place of Presentation: 石川
• [Presentation] Activation of MMP-2 and MMP-9 during Deterioration of Deep Tissue Injury in Rats (2011)
  • Author(s): Sari Y, Minematsu T, Nakagami G, Akase T, Nagase T, Oe M, Mori T, Sugama J, Sanada H
  • Organizer: 第13回日本褥瘡学会学術集会
  • Place of Presentation: 福岡
• [Presentation] Vibration attenuates the deterioration of deep tissue injury (2011)
  • Author(s): Sari Y, Minematsu T, Nakagami G, Akase T, Nagase T, Oe M, Mori T, Sugama J, Sanada H
  • Organizer: 第13回日本褥瘡学会学術集会
  • Place of Presentation: 福岡
• [Presentation] Vibration attenuates the deterioration of deep tissue injury. (2011)
  • Author(s): Yunita S, Minematsu T, Nakagami G, Akase T, Nagase T, et al.
  • Organizer: 第13回日本褥瘡学会学術集会
  • Place of Presentation: 福岡国際会議場（福岡県 福岡市）
• [Presentation] Activation of MMP-2 and MMP-9 during Deterioration of Deep Tissue Injury in Rats. (2011)
  • Author(s): Yunita S, Minematsu T, Nakagami G, Akase T, Nagase T, et al.
  • Organizer: 第13回日本褥瘡学会学術集会
  • Place of Presentation: 福岡国際会議場（福岡県 福岡市）
• [Presentation] Establishment of novel model for deterioration of deep tissue injury in rat. (2011)
  • Author(s): Yunita S, Minematsu T, Nakagami G, Akase T, Nagase T, et al.
  • Organizer: 第20回日本創傷・オストミー・失禁管理学会学術集会
  • Place of Presentation: 金沢歌劇座（石川県 金沢市）
• [Book] Chapter 3, Nursing Biology. In, Bioengineering Nursing : New horizons of nursing research (Sanada H, Mori T & Nagase T, Eds) (2014)
  • Author(s): Minematsu T, Tamai N, Nishijima Y
  • Publisher: Nova Science Publisher