| Project/Area Number |
23615005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Reliable environmental measurement methods
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| Research Institution | Toyohashi University of Technology |
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Principal Investigator |
HATTORI Toshiaki 豊橋技術科学大学, 工学(系)研究科(研究院), 准教授 (80198762)
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| Co-Investigator(Renkei-kenkyūsha) |
OKUMURA Koichi 公益財団法人科学技術交流財団, 知の拠点重点プロジェクト総括部, 主幹研究員
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | CCD型イオンイメージセンサ / 半導体アレイセンサ / 非侵襲測定 / 可塑化ポリ塩化ビニル膜 / 生細胞観察 / イオン交換樹脂 / 肥満細胞 / 細胞外イオン濃度 / イオンセンサ / イオンイメージングデバイス / 可塑化ポリ塩化ビニル / 細胞計測 / 半導体センサ / CCD / PC12 / 海馬 / イオンイメージセンサ / 動画計測 / インクジェット / 顆粒放出 / ヒスタミン / Hela細胞 / イオンイメージ / カルシウムイオン / ニュートラルキャリヤー / アセチルコリン / 細胞観察 |
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| Research Abstract |
We developed several new CCD-type ion image sensors using plasticized poly(vinyl chloride) membrane (Ion Microscopes), in order to monitor extracellular concentration of analyte ions released from cells or adsorbed into cells by stimulation of chemicals. The ion microscope developed could be applied to micro observation of living cells actually. In addition, we examined inhibiting effect of plasticized poly(vinyl chloride) membranes during the cultivation of cells, and we obtained some guidelines of preparing safety and non-invasive membrane.
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