| Project/Area Number |
23615012
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Reliable environmental measurement methods
|
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
IZUMI Hiroshi 独立行政法人産業技術総合研究所, 環境管理技術研究部門, 主任研究員 (20356455)
|
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| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 生体高分子 / 立体配座 / 超二次構造 / タンパク質 / 構造アライメント / 構造活性相関 / 赤外円二色性分光法 / 免疫 / ケモインフォマティクス / 多型 / 自己抗体 / 主要組織適合遺伝子複合体 |
|---|
| Research Abstract |
Supersecondary structure code (SSC) for 3D structural alignment of proteins was proposed, and the database of conformational code for 7494 subunits of proteins was constructed. The search method using these codes extracted the characteristic supersecondary structures (the structural regions in globular proteins folded into repetitive units) of immune factors related to self-recognition, and the fragment structures were represented as the simple description. Further, the conformational search techniques for absolute configuration determination of chiral compounds using vibrational circular dichroism (VCD) spectroscopy were transferred to a company.
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