Why methylation and demethylation occur simultaneously in cancers

• Project/Area Number: 23616001
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: epigenetics
• Research Institution: Gunma University
• Principal Investigator: HATADA Izuho 群馬大学, 生体調節研究所, 教授 (50212147)
• Co-Investigator(Kenkyū-buntansha): 堀居 拓郎 群馬大学, 生体調節研究所, 助教 (00361387) ; 落谷 孝広 独立行政法人国立がん研究センター, 研究所, 分野長 (60192530)
• Co-Investigator(Renkei-kenkyūsha): 落合 孝広 (60192530)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: メチル化 / エピジェネティクス

Research Abstract

DNA methylation is one of the modification of genes, which work as a gene switch. It inactivates tumor suppressor and cause cancer. We found specific isoform of DNMT3B DNA methyltranserase, which could cause cancer.

Research Products

• [Journal Article] Generation of an ICF Syndrome Model by Efficient Genome Editing of Human Induced Pluripotent Stem Cells Using the CRISPR System (2013)
  • Author(s): Horii T, Tamura D, Morita S, Kimura M, Hatada I
  • Journal Title: Int J Mol Sci Volume: 14 Pages: 19774-19781
• [Journal Article] Generation of an ICF Syndrome Model by Efficient Genome Editing of Human Induced Pluripotent Stem Cells Using the CRISPR System. (2013)
  • Author(s): Horii T, Tamura D, Morita S, Kimura M, , Hatada I
  • Journal Title: Int J Mol Sci Volume: 14 Issue: 10 Pages: 19774-19781
  • DOI: 10.3390/ijms141019774
  • Peer Reviewed
• [Journal Article] The Dnmt3b Splice Variant is Specifically Expressed in In Vitro-manipulated Blastocysts and Their Derivative ES Cells (2011)
  • Author(s): Horii T, Suetake I, Yanagisawa E, Morita S, Kimura M, Nagao Y, Imai H, Tajima S, Hatada I
  • Journal Title: J Reprod Dev Volume: 57 Pages: 579-585
  • NAID: 10029878177
• [Journal Article] The Dnmt3b splice variant is specifically expressed in in vitro-manipulated blastocysts and their derivative ES cells (2011)
  • Author(s): Horii T, Suetake I, Yanagisawa E, Kimura M, Morita S, Nagao Y, Imai H, Tajima S, Hatada I.
  • Journal Title: J Reprod Dev Volume: 57 Pages: 579-585
  • NAID: 10029878177
  • Peer Reviewed