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Analysis of physiological and nutritional features of collagen derived peptides

Research Project

Project/Area Number 23617002
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Integrated Nutrition Science
Research InstitutionUtsunomiya University

Principal Investigator

KABUYAMA Yukihito  宇都宮大学, 農学部, 教授 (20285042)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsコラーゲン / 皮膚再生 / 抗酸化 / 機能性食品 / コレステロール代謝 / 栄養生理 / 組織再生
Research Abstract

Collagen is the most abundant protein within extracellular matrix. Generally, collagen is thought to be inedible because it is fibrous protein. However, recent research has demonstrated that collagen could be one of the functional foods. In this study, we analyzed the physiological and nutritional features of collagen hydrolysates. The results showed that ingestion of collagen hydrolysates stimulated wound healing process in skin. Also, collagen has been shown to suppress blood cholesterol levels. Finally we found strong anti-oxidative activity one of the collagen-derived tripeptide. Together, these results suggested that collagen have excellent potential as functional food ingredients, effective for management and treatment of chronic diseases of the modern age.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (18 results)

All 2014 2013 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (15 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] Identification of a nitric oxide generation-stimulative principle in Scutellariae radix2013

    • Author(s)
      Chen Z, Nihei K, Tanaka H, Uda Y, Kabuyama Y
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 77(3) Pages: 657-9

    • NAID

      10031164792

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a Nitric Oxide Generation-Stimulative Principle in <i>Scutellariae radix</i>2013

    • Author(s)
      Ziyang Chen, Kenichi Nihei, Hideyuki Tanaka, Yasushi Uda, Yukihito Kabuyama
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 77 Issue: 3 Pages: 657-659

    • DOI

      10.1271/bbb.120800

    • NAID

      10031164792

    • ISSN
      0916-8451, 1347-6947
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 皮膚創傷回復モデルにおける魚由来コラーゲンペプチドの投与効果2013

    • Author(s)
      松崎史絵,早川薫,蕪山由己人
    • Organizer
      日本アミノ酸学会第7回学術大会
    • Place of Presentation
      熊本市医師会館
    • Related Report
      2013 Annual Research Report
  • [Presentation] コラーゲンペプチドによる皮膚培養細胞におけるMMP9の発現誘導2013

    • Author(s)
      濱田珠世,蕪山由己人
    • Organizer
      日本アミノ酸学会第7回学術大会
    • Place of Presentation
      熊本市医師会館
    • Related Report
      2013 Annual Research Report
  • [Presentation] ラットにおけるコラーゲンペプチドの消化吸収および代謝動態2013

    • Author(s)
      大澤吉弘,蕪山由己人
    • Organizer
      日本アミノ酸学会第7回学術大会
    • Place of Presentation
      熊本市医師会館
    • Related Report
      2013 Annual Research Report
  • [Presentation] 加水分解コラーゲンの吸収2013

    • Author(s)
      蕪山由己人
    • Organizer
      美容・アンチエイジング食品研究会&機能性食品用ペプチド研究会第3回合同研究会
    • Place of Presentation
      ロート製薬(株)会議室
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] ラットにおけるコラーゲンペプチドの腸管消化吸収形態2012

    • Author(s)
      大澤吉弘,蕪山由己人
    • Organizer
      日本アミノ酸学会 第6回学術大会
    • Place of Presentation
      千葉大学松戸キャンパス
    • Related Report
      2012 Research-status Report
  • [Presentation] ラットにおけるコラーゲンペプチドの腸管吸収形態2011

    • Author(s)
      大澤吉弘,田中秀幸,蕪山由己人
    • Organizer
      日本アミノ酸学会第5回学術大会
    • Place of Presentation
      名古屋大学シンポジオン
    • Related Report
      2011 Research-status Report
  • [Presentation] コラーゲン由来抗酸化ペプチドの創製2011

    • Author(s)
      鈴木稔朗,安保充,田中秀幸,吉村悦郎,蕪山由己人
    • Organizer
      日本アミノ酸学会第5回学術大会
    • Place of Presentation
      名古屋大学シンポジオン
    • Related Report
      2011 Research-status Report
  • [Presentation] メラノーマ浸潤に関与するアミノ酸代謝関連新規分子の同定2011

    • Author(s)
      蕪山由己人
    • Organizer
      第13回アミノ酸セミナー・基礎と臨床を結ぶ会(招待講演)
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2011 Research-status Report
  • [Presentation] Up-regulation of dermal matrix metalloproteinase 9 in the wound healing process by the oral administration of collagen hydrolysate2011

    • Author(s)
      Yukihito Kabuyama
    • Organizer
      2011 International conference on food factors(招待講演)
    • Place of Presentation
      Taipei
    • Related Report
      2011 Research-status Report
  • [Presentation] コラーゲン由来抗酸化ペプチドの創製

    • Author(s)
      鈴木稔朗,安保充,田中秀幸,吉村悦郎,蕪山由己人
    • Organizer
      日本アミノ酸学会第5回学術大会
    • Related Report
      2013 Final Research Report
  • [Presentation] ラットにおけるコラーゲンペプチドの腸管吸収動態

    • Author(s)
      大澤吉弘,田中秀幸,蕪山由己人
    • Organizer
      日本アミノ酸学会第5回学術大会
    • Related Report
      2013 Final Research Report
  • [Presentation] ラットにおけるコラーゲンペプチドの腸管吸収動態

    • Author(s)
      大澤吉弘,蕪山由己人
    • Organizer
      日本アミノ酸学会第6回学術大会
    • Related Report
      2013 Final Research Report
  • [Presentation] 皮膚創傷回復モデルにおける魚由来コラーゲンペプチドの投与効果

    • Author(s)
      松崎史絵,早川薫,蕪山由己人
    • Organizer
      日本アミノ酸学会第7回学術大会
    • Related Report
      2013 Final Research Report
  • [Presentation] コラーゲンペプチドによる皮膚培養細胞におけるMMP-9の発現誘導

    • Author(s)
      濱田珠世,蕪山由己人
    • Organizer
      日本アミノ酸学会第7回学術大会
    • Related Report
      2013 Final Research Report
  • [Presentation] ラットにおけるコラーゲンペプチドの消化吸収及び代謝動態

    • Author(s)
      大澤吉弘,蕪山由己人
    • Organizer
      日本アミノ酸学会第7回学術大会
    • Related Report
      2013 Final Research Report
  • [Book] 生化学2014

    • Author(s)
      小野寺一清,蕪山由己人
    • Publisher
      講談社
    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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