| Project/Area Number |
23617010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Osaka University |
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Principal Investigator |
KEN-ICHI Hirano 大阪大学, 医学(系)研究科(研究院), 助教 (30332737)
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Hiroyasu 奈良女子大学, 生活環境部, 教授 (40183743)
TAKENAKA Masaru 神戸女子大学, 家政学部, 教授 (20222101)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | 中性脂肪 / 中性脂肪蓄積心筋血管症 / 栄養 / 中鎖脂肪酸 / 動脈硬化 |
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| Research Abstract |
Triglyceride deposit cardiomyovasculopathy (TGCV) is a novel clinical entity in which TG accumulates in both myocardium and coronary arteries, leading to severe heart disease. A known cause of TGCV is genetic mutations in the adipose triglyceride lipase (ATGL), an essential molecule for intracellular hydrolysis of TG. In this study, we examined in vitro and in vivo effect of medium chain triglyceride on intracellular TG metabolism in ATGL-deficient fibroblasts and ATGL knockout mice, respectively. Based up these results, we developed a dietary therapy in which majority of natural fata was replaced by MCT. We investigated the effect of MCT diet on cardiac and skeletal muscle symptoms in ATGL-deficient patients. The diet was tolerable and possibly favorable effects were observed.
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