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Anti-obesity mechanism of Pediococcus pentosaceus LP28 and its effect in overweight subjects

Research Project

Project/Area Number 23617013
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Integrated Nutrition Science
Research InstitutionHiroshima University

Principal Investigator

HIGASHIKAWA Fumiko  広島大学, 大学院医歯薬保健学研究院(薬), 特任准教授 (70346534)

Co-Investigator(Kenkyū-buntansha) SUGIYAMA Masanori  広島大学, 大学院医歯薬保健学研究院 (薬), 教授 (30106801)
NODA Masafumi  広島大学, 大学院医歯薬保健学研究院 (薬), 特任講師 (40457289)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords抗肥満効果 / 植物乳酸菌 / 臨床試験 / 生活習慣病 / メタボリック症候群 / 抗肥満作用
Research Abstract

Pediococcus pentosaceus LP28 (LP28), which has been isolated from a fruit "longan", has an anti-obesity effect in high fat diet-induced obese mice. The main aim of this study was to investigate whether LP28 is also effective in human. In a double-blind, randomized, placebo-controlled clinical trial, the overweight subjects aged 20-70 years whose BMI was between 25 and 30, were assigned one of the following three groups: placebo; live LP28; or heat-killed LP28. The intake of heat-killed LP28 for 12 weeks reduced BMI, body fat percentage, waist circumference, serum LDL cholesterol level, and LDL/HDL ratio compared with the placebo. Thus, LP28 is effective to improve obesity in human as well as mouse, demonstrating that LP28 will be a very useful tool to reduce the risk of or prevent metabolic syndrome.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (3 results)

All 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Book (1 results)

  • [Journal Article] Narandalai Danshiitsoodol植物乳酸菌を利用した保健機能性製品の開発2013

    • Author(s)
      杉山政則
    • Journal Title

      食品と開発

      Volume: 48(5) Pages: 81-83

    • Related Report
      2013 Final Research Report
  • [Journal Article] The obesity and fatty liver are reduced by plant-derived Pediococcus pentosaceus in high fat diet-induced obese mice2012

    • Author(s)
      Zhao, X., et al
    • Journal Title

      PLOS One

      Volume: 7 Issue: 2 Pages: e30696-e30696

    • DOI

      10.1371/journal.pone.0030696

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Book] 植物乳酸菌の挑戦-未病および生活習慣病から化粧品まで2012

    • Author(s)
      杉山政則
    • Total Pages
      149
    • Publisher
      広島大学出版会
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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