Study of dietary components that have anti-senescence and anti-stress effects in brain
Project/Area Number |
23617014
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Integrated Nutrition Science
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Research Institution | University of Shizuoka |
Principal Investigator |
UNNO Keiko 静岡県立大学, 薬学部, 准教授 (10106437)
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Co-Investigator(Kenkyū-buntansha) |
SUGIURA Minoru 農業生物系特定産業技術研究機構, 果樹研究所, 主任研究官 (10355406)
KONISHI Tomokazu 秋田県立大学, 生物資源科学部, 准教授 (00281650)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Keywords | 脳 / 老化 / 酸化ストレス / 社会心理ストレス / 社会心理的ストレス |
Research Abstract |
Catechins in green tea and beta-cryptoxanthin in Japanese mandarin orange suppressed senescence and age-related brain dysfunction in aged mice. The effective dose of these components suggests that green tea catechin and beta-cryptoxanthin prevent age-related brain dysfunction in human. Although accumulation of psychosocial stress accelerated brain senescence in mice, theanine, an amino acid in tea, suppressed stress-related brain dysfunction. Theanine had significant anti-stress effect in university students during pharmacy practice, suggesting that theanine prevents stress-related brain dysfunction in human.
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Report
(4 results)
Research Products
(79 results)
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[Journal Article] Anti-stress effect of theanine on students during pharmacy practice : Positive correlation among salivaryα-amylase activity, trait anxiety and subjective stress2013
Author(s)
Unno K, Tanida N, Ishii N, Yamamoto H, Iguchi K, Hoshino M, Takeda A, Ozawa H, Ohkubo T, Juneja LR, Yamada H
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Journal Title
Pharmacol Biochem Behav
Volume: 111
Pages: 128-135
DOI
Related Report
Peer Reviewed
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[Journal Article] Ingestion of theanine, an amino acid in tea, suppresses psychosocial stress in mice.2013
Author(s)
Keiko Unno, Kazuaki Iguchi, Naoki Tanida, Keisuke Fujitani, Nina Takamori, Hiroyuki Yamamoto, Naoto Ishii, Hiroko Nagano, Takashi Nagashima, Ayane Hara, Kayoko Shimoi, Minoru Hoshino
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Journal Title
Experimental Physiology
Volume: 98(1)
Issue: 1
Pages: 290-303
DOI
Related Report
Peer Reviewed
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[Journal Article] Active Component in Green Tea Catechins and Effective Intake Period for Prevention of Age-related Brain Dysfunction2011
Author(s)
Unno K, Yamamoto H, Ohtaki T, Ishikawa Y, Noda S, Maeda K, Fujitani K, Miyazaki H, Takabayashi F, Sasaki T, Hoshino M
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Journal Title
Anti-Aging Medicine
Volume: 8
Pages: 75-81
NAID
URL
Related Report
Peer Reviewed
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[Journal Article] Theanine intake improves the shortened lifespan, cognitive dysfunction and behavioral depression that are induced by chronic psychosocial stress in mice2011
Author(s)
Unno K, Fujitani K, Takamori N, Takabayashi F, Maeda K, Miyazaki H, Tanida N, Iguchi K, Shimoi K, Hoshino M
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Journal Title
Free Radical Res.
Volume: 45
Issue: 8
Pages: 966-974
DOI
Related Report
Peer Reviewed
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[Journal Article] Beta-Cryptoxanthin, Plentiful in Japanese Mandarin Orange, Prevents Age-related Cognitive Dysfunction and Oxidative Damage in Senescence-accelerated Mouse Brain2011
Author(s)
Unno K, Sugiura M, Ogawa K, Takabayashi F, Toda M, Sakuma M, Maeda K, Fujitani K, Miyazaki H, Yamamoto H, Hoshino M
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Journal Title
Biol. Pharm. Bull
Volume: 34
Pages: 311-317
NAID
URL
Related Report
Peer Reviewed
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[Journal Article] Beta-cryptoxanthin, plentiful in Japanese mandarin orange, prevents age-related cognitive dysfunction and oxidative damage in senescence-accelerated mouse brain.2011
Author(s)
Unno K, Sugiura M, Ogawa K, Takabayashi F, Toda M, Sakuma M, Maeda K, Fujitani K, Miyazaki H, Yamamoto H, Hoshino M.
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Journal Title
Biol Pharm Bull
Volume: 34
Pages: 311-317
NAID
Related Report
Peer Reviewed
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[Journal Article] Active component in green tea catechins and effective intake period for prevension of age-related brain dysfunction2011
Author(s)
Unno K, Yamamoto H, Ohtaki T, Ishikawa Y, Noda S, Maeda K, Fujitani K, Miyazaki H, Takabayashi F, Sasaki T, Hoshino H.
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Journal Title
Anti-aging Medicine
Volume: 6
Pages: 75-81
Related Report
Peer Reviewed
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[Presentation] Anti-Aging Effect of β-Cryptoxanthin and Japanese Mandarin Orange in Brain of Mice2013
Author(s)
Naoto Ishii, Minoru Sugiura, Kazunori Ogawa, Naoki Tanida, Ayane Hara, Fumiyo Takabayashi, Atsushi Takeda, Minoru Hoshino, Tomokazu Konishi, and Keiko Unno
Organizer
13th International Conference of functional and medical foods with bioactive compounds, science and practical application
Place of Presentation
Kyoto, Japan
Related Report
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[Presentation] Anti-stress effect of theanine in mice and human2013
Author(s)
Naoto Ishii, Naoki Tanida, Ayane Hara, Hiroyuki Yamamoto, Kazuaki Iguchi, Astushi Takeda, Minoru Hoshino, Hayato Ozawa, Tsutomu Ohkubo, Lekh Raj Juneja, Hiroshi Yamada, Keiko Unno
Organizer
The 5th International Conference on O-CHA (Tea) Culture and Science
Place of Presentation
Shizuoka
Related Report
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[Presentation] Anti-stress effect of theanine in mice: Suppression of accelerated brain aging and shortened lifespan under psychosocial stress2011
Author(s)
Keiko Unno, K. Fujitani, T. Konishi, N. Takamori, N. Tanida, N. Ishii, F. Takabayashi, H. Yamamoto, K. Iguchi, K. Shimoi, M. Hoshino
Organizer
011 Annual Meeting of the International Society for Nutraceuticals and Functional Foods
Place of Presentation
Sapporo
Related Report
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[Presentation] Green tea components catechin and theanine are differently involved in the suppression of brain aging.
Author(s)
Keiko Unno, K. Iguchi, H. Yamamoto, T. Ohtaki, N. Tanida, Y. Narita, S. Hagiwara, F. Takabayashi, K. Shimoi, T. Ohkubo, L. R. Juneja, M. Hoshino
Organizer
The 1st International Conference on Pharma and Food
Place of Presentation
静岡
Related Report
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[Presentation] 脳の老化予防
Author(s)
海野けい子
Organizer
シーズ&ニーズビジネスマッチング研究発表会
Place of Presentation
静岡
Related Report
Invited
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[Presentation] Anti-Aging Effect of β-Cryptoxanthin and Japanese Mandarin Orange in Brain of Mice
Author(s)
Naoto Ishii, Minoru Sugiura, Kazunori Ogawa, Naoki Tanida, Ayane Hara, Fumiyo Takabayashi, Atsushi Takeda, Minoru Hoshino, Tomokazu Konishi, and Keiko Unno
Organizer
13th International Conference of functional and medical foods with bioactive compounds, science and practical application
Place of Presentation
京都
Related Report
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