| Project/Area Number |
23617017
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Osaka City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KONISHI Yotaro 大阪市立大学, 大学院生活科学研究科, 教授 (70116812)
INUI Hiroshi 大阪市立大学, 生命環境科学研究科, 教授 (20193568)
KIKUZAKI Hiroe 奈良女子大学, 生活環境学部, 教授 (60291598)
TAKADA Jiro 福岡大学, 薬学部, 教授 (90122704)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 線虫 / 老化 / 生体防御 / 栄養 / 抗酸化物質 / 乳酸菌 / 自然免疫 / 機能性食品因子 / 食品因子 |
|---|
| Research Abstract |
The nematode, Caenorhabditis elegans, was used to screen lipid-soluble substances, particularly antioxidants, for the lifespan-prolonging effect. Tocotrienols, astaxanthin, sesamin, and the cell wall of bifidobacteria could extend the lifespan of the nematode. These substances enhanced the worm's tolerance to stresses due to heat, UV irradiation, oxidative chemicals, or bacterial infection; these substances could protect the worms from aging-associated weakness of locomotive ability. Each substance gave the different phenotype of tolerance. The mutants which have loss-of-function genes on the signal induction pathways of p38 MAPK or Insulin/IGF for host defense were used to elucidate the mechanism of the anti-senescence effects. Each functional food factor was definitely dependent on these pathways in different manners.
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