| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Research Abstract |
The hyperphosphatemia is observed at high ratio in the hemodialysis patients, and the phosphate (Pi) management is important because this leads of one's death by the cardiovascular disease by the ectopic calcification. Especially, Pi sensor and Pi channel are key protein to clear the ectopic calcification in bone. In this research, we tried to clarify the calcification mechanism by characterization of the Pi channel in the bone and/or the vascular endothelial.
In this research, we indicated the molecular regulation and function of Pi channel and role of the ectopic calcification in calcificated Human Aortic Smooth Muscle Cells.
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