| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Cellular mechanism underlying acyclic retinoid of geranylgeranoic acid (GGA)-mediated induction of cell death in human hepatoma cells was investigated. In hepatoma cells, GGA induces initial autophagy, but incomplete autophagic response, which lacks autolysosome formation. As a cellular mechanism of GGA-induced initial autophagy, we observed 1) nuclear translocation of mutant p53, 2) hyperproduction of superoxide, and 3) unfolded protein response (UPR) in ER. The present study revealed that GGA induces initial autophagy through ER-UPR, which may result in cell death.
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