Prevention of human hepatoma with acyclic retinoids
| Project/Area Number |
23617020
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | University of Nagasaki |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | オートファジー / 非環式レチノイド / ゲラニルゲラノイン酸 / オートファゴソーム / 細胞死 / 癌予防 / UPR / XBP1 splicing / mutant p53 / superoxide / autophagy flux / Rab7 / autolysosome / geranylgeranoic acid / 肝癌 / オートリソソーム |
|---|
| Research Abstract |
Cellular mechanism underlying acyclic retinoid of geranylgeranoic acid (GGA)-mediated induction of cell death in human hepatoma cells was investigated. In hepatoma cells, GGA induces initial autophagy, but incomplete autophagic response, which lacks autolysosome formation. As a cellular mechanism of GGA-induced initial autophagy, we observed 1) nuclear translocation of mutant p53, 2) hyperproduction of superoxide, and 3) unfolded protein response (UPR) in ER. The present study revealed that GGA induces initial autophagy through ER-UPR, which may result in cell death.
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Report
(4 results)
Research Products
(65 results)
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[Journal Article] CXCR4-tropic, but not CCR5-tropic, human immunodeficiency virus infection is inhibited by the lipid raft-associated factors, acyclic retinoid analogs, and cholera toxin B subunit2013
Author(s)
Kamiyama H, Kakoki K, Shigematsu S, Izumida M, Yashima Y, Tanaka Y, Hayashi H, Matsuyama T, Sato H, Yamamoto N, Sano T, Shidoji Y, Kubo Y.
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Journal Title
AIDS Res Hum Retroviruses
Volume: 29
Pages: 279-288
NAID
Related Report
Peer Reviewed
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[Journal Article] CXCR4-tropic, but not CCR5-tropic, human immunodeficiency virus infection is inhibited by the lipid raft-associated factors, acyclic retinoid analogs, and cholera toxin B subunit2013
Author(s)
H. Kamiyama, K. Kakoki, S. Shigematsu, M. Izumida, Y. Yashima, Y. Tanaka, H. Hayashi, T. Matsuyama, H. Sato, N. Yamamoto, T. Sano, Y. Shidoji, Y. Kubo
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Journal Title
AIDS Res.Hum.Retrovir.
Volume: 29
Issue: 2
Pages: 279-88
DOI
NAID
Related Report
Peer Reviewed
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