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The transport of polyunsaturated fatty acids across the placenta to the fetus and the subsequent growth and development of the infant

Research Project

Project/Area Number 23617025
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Integrated Nutrition Science
Research InstitutionKagawa Nutrition University

Principal Investigator

KAWABATA Terue  女子栄養大学, 栄養学部, 教授 (80190932)

Co-Investigator(Kenkyū-buntansha) NAKAI Kunihiko  東北大学, 大学院医学系研究科, 教授 (00291336)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsn-3系多価不飽和脂肪酸 / 母児間移行 / n-6系多価不飽和脂肪酸 / 臍帯血 / 母体血 / ω3多価不飽和脂肪酸 / 妊産婦栄養 / 出生コホート / 神経行動学的発達
Research Abstract

We analyzed the polyunsaturated fatty acid (PUFA) compositions in maternal and cord blood erythrocytes of 523 pregnant women living along the shore of the Miyagi prefecture and determined the transport of arachidonic acid (ARA) and docosahexaenoic acid (DHA) across the placenta to the fetus. The PUFA levels of infants reflected those of their mothers, indicating that PUFA transport across the placenta to the fetus determined the PUFA compositions in cord blood erythrocytes. In the third trimester, the ARA level in maternal erythrocytes decreased compared with that in the second trimester, but no change in maternal DHA was observed. This finding suggested that the DHA in maternal blood satisfied the increasing demand of the fetus in the third trimester.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (12 results)

All 2014 2013 2012 2011

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (8 results)

  • [Journal Article] Influences of stearidonic acid-enriched soybean oil on the blood and organ biochemical parameters in rats.2013

    • Author(s)
      Kawabata T, Shimoda K, Horiguchi S, Domon M, Hagiwara C, Takiyama M, Kagawa Y.
    • Journal Title

      Prostaglandins Leukot Essent Fatty Acids.

      Volume: 88 Issue: 2 Pages: 179-184

    • DOI

      10.1016/j.plefa.2012.11.004

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prenatal exposures to environmental chemicals and birth order as risk factors for child behavior problems.2012

    • Author(s)
      Tatsuta N, Nakai K, Murata K, Suzuki K, Iwai-Shimada M, Yaginuma-Sakurai K, Kurokawa N, Nakamura T, Hosokawa T, Satoh H.
    • Journal Title

      Environ Research

      Volume: 114 Pages: 47-52

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Age-related changes of dietary intake and blood eicosapentaenoic acid, docosahexaenoic acid, and arachidonic acid levels in Japanese men and women.2011

    • Author(s)
      Kawabata T, Hirota S, Hirayama T, Adachi N, Hagiwara C, Iwama N, Kamachi K, Araki E, Kawashima H, Kiso Y.
    • Journal Title

      Prostaglandins Leukot Essent Fatty Acids.

      Volume: 84 Pages: 131-137

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Associations between dietary n-6 and n-3 fatty acids and arachidonic acid compositions in plasma and erythrocytes in young and elderly Japanese volunteers.2011

    • Author(s)
      Kawabata T, Hirota S, Hirayama T, Adachi N, Kaneko Y, Iwama N, Kamachi K, Araki E, Kawashima H, Kiso Y.
    • Journal Title

      Lipids Health Dis.

      Volume: 10 Issue: 1 Pages: 138-138

    • DOI

      10.1186/1476-511x-10-138

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 母体血および臍帯血赤血球中脂肪酸組成と非妊娠時BMIとの関連2014

    • Author(s)
      下田和美、川端輝江、香川靖雄、木村ふみ子、宮澤陽夫、仲井邦彦、有馬隆博、水野聖士、八重樫伸生
    • Organizer
      第68回日本栄養・食糧学会大会
    • Place of Presentation
      北海道
    • Related Report
      2013 Final Research Report
  • [Presentation] 母体血および臍帯血赤血球中脂肪酸組成と非妊娠時BMIとの関連2014

    • Author(s)
      下田和美、川端輝江、香川靖雄、木村ふみ子、宮澤陽夫、仲井邦彦、有馬隆博、水野聖士、八重樫伸生
    • Organizer
      第68回日本栄養・食糧学会大会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 母体および臍帯赤血球中脂肪酸組成と出産に関わる各種指標との関連2013

    • Author(s)
      下田和美、川端輝江、香川靖雄、木村ふみ子、宮澤陽夫、仲井邦彦、有馬隆博、八重樫伸生
    • Organizer
      日本脂質栄養学会第22回大会
    • Place of Presentation
      高知県
    • Related Report
      2013 Final Research Report
  • [Presentation] 妊娠期の脂肪酸栄養に関する研究,母体および臍帯赤血球中n-3系・n-6系長鎖多価不飽和脂肪酸組成の比較2013

    • Author(s)
      川端輝江、香川靖雄、木村ふみ子、宮澤陽夫、仲井邦彦、有馬隆博、八重樫伸生
    • Organizer
      第67回日本栄養・食糧学会大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] 妊娠期の脂肪酸栄養に関する研究 母体および臍帯赤血球中n-3系・n-6系長鎖多価不飽和脂肪酸組成の比較2013

    • Author(s)
      川端輝江、香川靖雄、木村ふみ子、宮澤陽夫、仲井邦彦、有馬隆博、八重樫伸生
    • Organizer
      第67回日本栄養・食糧学会大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 母体および臍帯赤血球中脂肪酸組成と出産に関わる各種指標との関連2013

    • Author(s)
      下田和美、川端輝江、香川靖雄、木村ふみ子、宮澤陽夫、仲井邦彦、有馬隆博、八重樫伸生
    • Organizer
      日本脂質栄養学会第22回大会
    • Place of Presentation
      高知市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 食物摂取を介した環境由来化学物質の摂取とその健康リスク2012

    • Author(s)
      仲井邦彦
    • Organizer
      第66回日本栄養・食糧学会大会・シンポジウム
    • Place of Presentation
      宮城県仙台市
    • Related Report
      2012 Research-status Report
  • [Presentation] 東北沿岸部における小児出生コホート調査の到達点と東日本大震災被災地としての課題2012

    • Author(s)
      仲井邦彦
    • Organizer
      第82回日本衛生学会総会
    • Place of Presentation
      京都市(京都大学)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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