Clinical research on the central nervous system disorder by quantitative determination of serum tryptophan metabolites
| Project/Area Number |
23617027
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Toho University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUKUSHIMA Takeshi 東邦大学, 薬学部, 教授 (00272485)
ICHIBA Hideaki 東邦大学, 薬学部, 講師 (80120236)
SADAMOTO Kiyomi 東邦大学, 薬学部, 教授 (00297673)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 中枢性精神疾患 / 統合失調症 / Ｌｰトリプトファン / L-キヌレニン / セロトニン / LC-MS / HPLC / 蛍光検出 / 中枢性疾患 / トリプトファン / トリプトファン代謝物 / アミノ酸 / 遊離脂肪酸 / 多変量解析 / 蛍光誘導体化 / LCーMS / DBD-PyNCS / 蛍光誘導体化法 |
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| Research Abstract |
In the brain tissue (nucleus accumbens and hippocampus) of phencyclidine-treated mice which is an animal model of schizophrenia, the L-tryptophan (L-Trp)concentration was significantly decreased. This result suggested that dysregulation of L-Trp metabolism occurred in these brain regions.
In the present study, a significant gender difference was observed, namely, L-Trp concentration in the sera of male healthy subjects was higher than that of female healthy subjects. A significant correlation was observed between L-Trp and L-KYN concentrations in male, but not in female subjects. The serum levels of L-Trp, KYN, and serotonin were significantly different between controls and schizophrenia patients, suggesting that determinations of L-Trp, KYN, and 5-HT in serum might be crucial for clinical diagnosis.
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Report
(4 results)
Research Products
(38 results)
