A potential modulation of mast cell function by nutritional factors
| Project/Area Number |
23617028
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Sagami Women's University |
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Principal Investigator |
MASUKO Kayo 相模女子大学, 栄養科学部, 教授 (80288208)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 肥満細胞 / 栄養 / ヒスタミン / グルタミン / アルギニン |
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| Research Abstract |
[Background] Mast cell activation has been implicated in wound healing via releasing a variety of mediators. Glutamine (Gln) and arginine (Arg) are used as "immunonutrients" in malnourished patients, but their potential effect on mast cells is unclear. We evaluated the effect of Gln and/or Arg on mast cell function. [Methods] P815 cells were cultured in a medium under different Gln and/or Arg concentrations. Histamine and IL-13 release was measured using enzyme-linked immunoassays. [Results and Discussion] Cells cultured in higher Gln concentrations produced a greater histamine response upon IL-6 stimulation. IL-13 production was not significantly altered by IL-6 stimulation or by Arg concentration. [Conclusions] Gln and/or Arg concentrations in situ may regulate histamine and IL-13 release from mast cells. The appropriate use of functional amino acids as immunonutrients may suppress inflammation and aid in wound healing.
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Report
(4 results)
Research Products
(52 results)
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[Journal Article] Expression of Angiotensin II Receptor-1 in Human Articular Chondrocytes2012
Author(s)
Kawakami Y, Matsuo K, Murata M, Yudoh K, Nakamura H, Shimizu H, Beppu M, Inaba Y, Saito T, Kato T, Masuko K.
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Journal Title
Arthritis
Volume: 2012
Pages: 648537-648537
DOI
Related Report
Peer Reviewed
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[Journal Article] Arthritogenicity of annexin VII revealed by phosphoproteomics of rheumatoid synoviocytes2011
Author(s)
Matsuo K, Arito M, Noyori K, Nakamura H, Kurokawa MS, Masuko K, Okamoto K, Nagai K, Suematsu N, Yudoh K, Beppu M, Saito T, Kato T.
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Journal Title
Ann Rheum Dis
Volume: 70
Pages: 1489-95
Related Report
Peer Reviewed
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