| Project/Area Number |
23617029
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
TANAKA YASUSHI 聖マリアンナ医科大学, 医学部, 教授 (40276499)
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| Co-Investigator(Renkei-kenkyūsha) |
OHTA Akio 聖マリアンナ医科大学, 医学部, 准教授 (20233116)
KATABAMI Takuyuki 聖マリアンナ医科大学, 医学部, 准教授 (70257369)
KATO Hiroyuki 聖マリアンナ医科大学, 医学部, 講師 (50440350)
ASAI Shiko 聖マリアンナ医科大学, 医学部, 助教 (10534208)
FURUKAWA Kentaro 聖マリアンナ医科大学, 医学部, 助教 (50590791)
OHMORI Shintaro 聖マリアンナ医科大学, 医学部, 助教 (00410077)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 内科 / 栄養学 / 糖尿病 / 生理学 / 食品 |
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| Research Abstract |
We investigated to establish suitable diet plan for Japanese obese subjects with metabolic syndrome (METS) to prevent lifestyle-related disease and contribute to health promotion. To evaluate effect of diet on body fat composition, we performed 1H-MRS and whole abdominal CT-scanning by 700-800 slices for quantitative measurement of liver fat content and abdominal visceral and subcutaneous fat volume, respectively. In results, total energy of 28 kcal/ideal body weight kg, and nutritional balance of carbohydrate 50-55 %, fat 25-30 %, and protein 15-20 % was reduced liver fat by 56 % and visceral fat volume and abdominal subcutaneous fat volume equally by 22 %, and improved clinical parameters such as blood pressure, plasma glucose and lipids, or HOMA-R. Furthermore, throughout this diet period for 1 year, no case of drop out or showing rebound of body eight was observed. Consequently, this diet plan is recommendable to Japanese subjects with obese and METS subjects.
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