Roles of fat-soluble nutrients in the development of neural circuits supporting parental infant relationship.
Project/Area Number |
23617034
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Integrated Nutrition Science
|
Research Institution | Yasuda Women's University |
Principal Investigator |
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Project Period (FY) |
2011-04-28 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 視床下部 / 縫線核 / トコトリエノール / エストロゲン受容体 / 小脳 / 脳スライス培養 / in situ ハイブリダイゼーション / 免疫組織化学 / 養育行動中枢 / 愛着行動中枢 / ビタミンE / 脂肪酸結合タンパク質 / ハイブリダイゼーション / 免疫組織細胞化学 |
Outline of Final Research Achievements |
Fostering ties between parents and children, and nurturing loving and committed relationships are fundamental to healthy dietary habit over a lifetime. Focusing on the hypothalamus and other brain regions involved in maternal, attachment, and anxiety-like behaviors, the effects of fat-soluble nutrients on neurogenesis and functional development of the neural circuits were investigated in mice. Using single living cell imaging analysis of GFP-tagged estrogen receptor beta, natural fat-soluble vitamin E tocotrienols were evaluated to act as ligand for the receptor. The effects of tocotrienols on neuronal differentiation are under investigation in either postnatal cerebellar or embryonic hypothalamic slice culture system.
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Report
(5 results)
Research Products
(7 results)
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[Presentation] Cerebellar Development Transcriptome Database (CDT-DB) - Profiling of Spatio-Temporal Gene Expression During Postnatal Development of Mouse Brain.2014
Author(s)
Shinoda, Y., Sato, A., Koebis, M., Sadakata, T., Morita, N., Yuzaki, M., Inoue, T., Nishibe, H.,Yamaguchi, Y. and Furuichi, T.
Organizer
INCF Japan Node International Workshop: Advances in Neuroinformatics 2014
Place of Presentation
Wako, Japan
Year and Date
2014-09-26
Related Report
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[Presentation] Cerebellar Development Transcriptome Database (CDT-DB).2014
Author(s)
Sato, A., Shinoda, Y., Koebis, M., Sadakata, T., Morita, N., Yuzaki, M., Inoue, T., Nishibe, H.,Yamaguchi, Y. and Furuichi, T.
Organizer
INCF Japan Node International Workshop: Advances in Neuroinformatics 2014
Place of Presentation
Wako, Japan
Year and Date
2014-09-25 – 2014-09-26
Related Report
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