| Project/Area Number |
23617034
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Yasuda Women's University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 視床下部 / 縫線核 / トコトリエノール / エストロゲン受容体 / 小脳 / 脳スライス培養 / in situ ハイブリダイゼーション / 免疫組織化学 / 養育行動中枢 / 愛着行動中枢 / ビタミンE / 脂肪酸結合タンパク質 / ハイブリダイゼーション / 免疫組織細胞化学 |
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| Outline of Final Research Achievements |
Fostering ties between parents and children, and nurturing loving and committed relationships are fundamental to healthy dietary habit over a lifetime. Focusing on the hypothalamus and other brain regions involved in maternal, attachment, and anxiety-like behaviors, the effects of fat-soluble nutrients on neurogenesis and functional development of the neural circuits were investigated in mice.
Using single living cell imaging analysis of GFP-tagged estrogen receptor beta, natural fat-soluble vitamin E tocotrienols were evaluated to act as ligand for the receptor. The effects of tocotrienols on neuronal differentiation are under investigation in either postnatal cerebellar or embryonic hypothalamic slice culture system.
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