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The study of the new function of amino acids containing fish and seafood on obesity and noncommunicable diseases (NCDs).

Research Project

Project/Area Number 23617039
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Integrated Nutrition Science
Research InstitutionNational Institute of Health and Nutrition

Principal Investigator

KASAOKA (TSUBOYAMA) Nobuyo (Nobuyo )  独立行政法人国立健康・栄養研究所, その他部局等, その他 (70321891)

Co-Investigator(Renkei-kenkyūsha) KASAOKA Seiichi  文教大学, 健康栄養学部, 教授 (00331455)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords肥満 / タウリン / ヒスチジン
Outline of Final Research Achievements

The purpose of this study is to find a countermeasure of overweight and noncommunicable diseases (NCDs) in Japan. The relation between blood taurine (2-aminoethanesulfonic acid) concentrations and obesity/ NCDs was investigated.
This study suggest that excess body fat accumulation causes depletion of the blood taurine concentration by decrease of taurine synthesis in white adipose tissue specific CDO overexpressed transgenic mice and obese human.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (31 results)

All 2015 2014 2013 2012 2011 Other

All Journal Article (11 results) (of which Peer Reviewed: 5 results) Presentation (13 results) (of which Invited: 4 results) Book (7 results)

  • [Journal Article] アミノ酸の機能 ~タウリンを中心として~2014

    • Author(s)
      笠岡(坪山)宜代
    • Journal Title

      New Diet therapy

      Volume: 30 Pages: 15-19

    • Related Report
      2014 Annual Research Report
  • [Journal Article] What factors were important for dietary improvement in emergency shelters after the Great East Japan Earthquake?2014

    • Author(s)
      Tsuboyama-Kasaoka N、Yuko Hoshi、Kazue Onodera、Shoichi Mizuno、Kazuko Sako
    • Journal Title

      Asia Pacific J Clinical Nutr

      Volume: 23(1) Pages: 159-166

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Stockpiles and food availability in feeding facilities after the Great East Japan Earthquake2014

    • Author(s)
      Nozue M、Ishikawa-Takata K、Sarukura N、Kazuko Sako、Tsuboyama-Kasaoka N
    • Journal Title

      Asia Pacific J Clinical Nutr

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] アミノ酸の機能 ~タウリンを中心として~2014

    • Author(s)
      笠岡(坪山)宜代
    • Journal Title

      New Diet therapy

      Volume: .

    • Related Report
      2013 Research-status Report
  • [Journal Article] Relationship of living conditions with dietary patterns among survivors of the Great East Japan Earthquake2013

    • Author(s)
      Nishi N、Yoshimura E、Ishikawa-Takata K、Tsuboyama-Kasaoka N、Kubota T、Miyachi M、Tokudome S、Yokoyama Y、Sakata K、Kobayashi S、Ogawa A
    • Journal Title

      J Epidemiol

      Volume: 23(5) Pages: 376-381

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Systematic classification of evidence for dietary reference intakes for Japanese 2010 (DRIs-J 2010) in adults and future prospects of DRIs in Asian countries2013

    • Author(s)
      Nakade M、Imai E、T.Utsugi M、Tsuboyama-Kasaoka N、Takimoto H
    • Journal Title

      Asia Pacific J Clin Nutr

      Volume: 22(4) Pages: 474-489

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dietary intake of nutrients with Adequate Intake values in the Dietary Reference Intakes for Japanese2013

    • Author(s)
      Tsuboyama-Kasaoka N、Takizawa A、T.Utsugi M、Nakade M、Imai E、Kondo A、Yoshida K、Okuda N、Nishi N、Takimoto H
    • Journal Title

      J Nutr Sci Vitaminol

      Volume: 59(6) Pages: 584-595

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Historical overview of the establishment of Dietary Reference Intakes for Japanese,2013

    • Author(s)
      Nobuyo Tsuboyama-Kasaoka, Megumi Tsubota-Utsugi, Eri Imai, Makiko Nakade, Masato Kasuga,
    • Journal Title

      J Nutr Sci Vitaminol  Supplement

      Volume: 59

    • Related Report
      2012 Research-status Report
  • [Journal Article] Dietary reference intakes for Japanese 2010: Carbohydrates,2013

    • Author(s)
      Kazuhiko Yamada, Nobuyo Tsuboyama-Kasaoka, Toshinao Goda, Kyoko Saito, Toshikazu Yamanouchi, Tetsuji Yokoyama, Osamu Chonan, Eri Imai, Makiko Nakade, Seiichiro Aoe,
    • Journal Title

      J Nutr Sci Vitaminol  Supplement

      Volume: 59

    • Related Report
      2012 Research-status Report
  • [Journal Article] 新たに発生した食品の安全性問題において参照される情報源に関する調査-エコナ油を事例として-2012

    • Author(s)
      吉本弥生, 笠岡(坪山)宜代, 山口亨,桂木能久,梅垣敬三,
    • Journal Title

      日本栄養士会雑誌

      Volume: 55(9) Pages: 732-741

    • Related Report
      2012 Research-status Report
  • [Journal Article] School-based "Shokuiku" program in Japan: application to nutrition education in Asian countries2012

    • Author(s)
      Miyoshi M、Tsuboyama-Kasaoka N、Nishi N
    • Journal Title

      Asia Pacific Journal of Clinical Nutrition

      Volume: 21 Pages: 159-162

    • Related Report
      2011 Research-status Report
  • [Presentation] 肥満とタウリン2015

    • Author(s)
      笠岡(坪山)宜代
    • Organizer
      第一回国際タウリン研究会 日本部会 シンポジウム
    • Place of Presentation
      神戸市
    • Year and Date
      2015-02-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 児童における血清含硫アミノ酸濃度と身体計測値との関連2014

    • Author(s)
      米山ひかる、細川優、笠岡(坪山)宜代、斉藤恵美子、瀧沢あす香、原光彦
    • Organizer
      日本栄養改善学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-08-20 – 2014-08-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] Nutritional status of children and their mothers, and its determinants in Port Moresby, Papua New Guinea,2011

    • Author(s)
      Miyoshi M、Tsuboyama-Kasaoka N、Nishi N、Job Hawap、Tadatoshi Kuratsuji
    • Organizer
      XI Asian Congress of Nutrition
    • Place of Presentation
      singapore
    • Related Report
      2011 Research-status Report
  • [Presentation] ダイエタリーサプリメントおよびいわゆる健康食品等に関連したリスク情報の諸外国での発信状況に関する研究2011

    • Author(s)
      笠岡(坪山)宜代、中西朋子、佐藤陽子、瀧沢あす香、石見佳子、梅垣敬三、芝池伸彰
    • Organizer
      第65回日本栄養食糧学会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] A Group Interview about Meal Services during Disaster at Nursery School in a Metropolitan Area

    • Author(s)
      Yukiko Amitani、Noriko Sudo、Tsuboyama-Kasaoka N、Fumiko Ishikawa、Kazuko Sako
    • Organizer
      8th Asia Pacific Conference on Clinical Nutrition
    • Place of Presentation
      Maihama
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Dose-dependent Effect Of Taurine Supplementation On Obesity And Hyperleptinemia In Mice

    • Author(s)
      Tsuboyama-Kasaoka N、Hosokawa Y
    • Organizer
      12th International Congress on Obesity
    • Place of Presentation
      Kuala Lumpur
    • Related Report
      2013 Research-status Report
  • [Presentation] アミノ酸の機能 ~タウリンを中心として~

    • Author(s)
      笠岡(坪山)宜代
    • Organizer
      日本臨床栄養学会サプリメントフォーラム
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 肥満・メタボリックシンドローム改善を目指した実食型フードモデルの有効性の検討

    • Author(s)
      瀧沢あす香、笠岡(坪山)宜代、西信雄、細川裕子、佐々木敏、岡純
    • Organizer
      第60回日本栄養改善学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
  • [Presentation] What factors were important for dietary improvement after the Great East Japan Earthquake?

    • Author(s)
      Tsuboyama-Kasaoka N、Kazuko Sako
    • Organizer
      8th Asia Pacific Conference on Clinical Nutrition
    • Place of Presentation
      Maihama
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Internet Computersystem by using linear programming for optimum community nutrition, lowcost food combination and recipe to support the dietitian activities on nutritional survey of the Great East Japan Earthquake Disaster

    • Author(s)
      masatoshi kajimoto, Nobuyo Tsuboyama-Kasaoka,
    • Organizer
      International Congress of Nutrition,
    • Place of Presentation
      Australia
    • Related Report
      2012 Research-status Report
  • [Presentation] The differencesof anthropometric and biological indicatorsby age and sexin healthy Japanese adults

    • Author(s)
      Eri Imai, Megumi Tsubota-Utsugi, Makiko Nakade, NobuyoTsuboyama-Kasaoka,
    • Organizer
      第59回日本栄養改善学会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] 食品情報の情報源に関する消費者調査

    • Author(s)
      吉本弥生、笠岡(坪山)宜代、山口亨、桂木能久、梅垣敬三、
    • Organizer
      第59回日本栄養改善学会
    • Place of Presentation
      9名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] 食品情報の情報源に関する調査

    • Author(s)
      吉本弥生1)、笠岡(坪山)宜代2)、山口亨1)、桂木能久1)、梅垣敬三
    • Organizer
      第71回公衆衛生学会
    • Place of Presentation
      山口
    • Related Report
      2012 Research-status Report
  • [Book] 同文書院2013

    • Author(s)
      笠岡(坪山)宜代
    • Total Pages
      2
    • Publisher
      田中平三、中村丁次編著日本栄養学教育学会監修 栄養学概論Capter06管理栄養士・栄養士と栄養実践活動の実際「世界の管理栄養士・栄養士」
    • Related Report
      2012 Research-status Report
  • [Book] 日本臨床栄養協会編  NR・SAテキスト 「第4章 人間栄養学」2013

    • Author(s)
      高田和子・笠岡(坪山)宜代
    • Total Pages
      17
    • Publisher
      第一出版
    • Related Report
      2012 Research-status Report
  • [Book] 「第13章 遺伝子と栄養現象」小林修平・山本 茂 編集 人体栄養学の基礎、第二版2012

    • Author(s)
      笠岡(坪山)宜代
    • Total Pages
      6
    • Publisher
      建帛社
    • Related Report
      2012 Research-status Report
  • [Book] 「Step3. 栄養介入」. 日本栄養士会編 国際標準化のための栄養ケアプロセス用語マニュアル2012

    • Author(s)
      笠岡(坪山)宜代
    • Total Pages
      1
    • Publisher
      第一出版社
    • Related Report
      2012 Research-status Report
  • [Book] 脂肪をためない4大食材&「いい油」の選び方・使い方 DHA・EPAが脂質を燃やす!筋肉アップにも効果40代からは魚をとろう!2011

    • Author(s)
      笠岡(坪山)宜代
    • Total Pages
      2
    • Publisher
      日経ヘルスプルミエ
    • Related Report
      2011 Research-status Report
  • [Book] Nブックス 三訂 応用栄養学 (日本人の食事摂取基準)2011

    • Author(s)
      笠岡(坪山)宜代
    • Total Pages
      21
    • Publisher
      建帛社
    • Related Report
      2011 Research-status Report
  • [Book] 建帛社2011

    • Author(s)
      森田明美、笠岡(坪山)宜代、田中清、上西一弘
    • Total Pages
      172
    • Publisher
      ポケット食事摂取基準 現場ですぐに役立つ「日本人の食事摂取基準(2010年版)」
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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