The study of the new function of amino acids containing fish and seafood on obesity and noncommunicable diseases (NCDs).

• Project/Area Number: 23617039
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Integrated Nutrition Science
• Research Institution: National Institute of Health and Nutrition
• Principal Investigator: KASAOKA (TSUBOYAMA) Nobuyo (Nobuyo ) 独立行政法人国立健康・栄養研究所, その他部局等, その他 (70321891)
• Co-Investigator(Renkei-kenkyūsha): KASAOKA Seiichi 文教大学, 健康栄養学部, 教授 (00331455)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 肥満 / タウリン / ヒスチジン

Outline of Final Research Achievements

The purpose of this study is to find a countermeasure of overweight and noncommunicable diseases (NCDs) in Japan. The relation between blood taurine (2-aminoethanesulfonic acid) concentrations and obesity/ NCDs was investigated.
This study suggest that excess body fat accumulation causes depletion of the blood taurine concentration by decrease of taurine synthesis in white adipose tissue specific CDO overexpressed transgenic mice and obese human.

Research Products

• [Journal Article] アミノ酸の機能 ～タウリンを中心として～ (2014)
  • Author(s): 笠岡（坪山）宜代
  • Journal Title: New Diet therapy Volume: 30 Pages: 15-19
• [Journal Article] What factors were important for dietary improvement in emergency shelters after the Great East Japan Earthquake? (2014)
  • Author(s): Tsuboyama-Kasaoka N、Yuko Hoshi、Kazue Onodera、Shoichi Mizuno、Kazuko Sako
  • Journal Title: Asia Pacific J Clinical Nutr Volume: 23(1) Pages: 159-166
  • Peer Reviewed
• [Journal Article] Stockpiles and food availability in feeding facilities after the Great East Japan Earthquake (2014)
  • Author(s): Nozue M、Ishikawa-Takata K、Sarukura N、Kazuko Sako、Tsuboyama-Kasaoka N
  • Journal Title: Asia Pacific J Clinical Nutr Volume: in press
  • Peer Reviewed
• [Journal Article] アミノ酸の機能 ～タウリンを中心として～ (2014)
  • Author(s): 笠岡(坪山)宜代
  • Journal Title: New Diet therapy Volume: .
• [Journal Article] Relationship of living conditions with dietary patterns among survivors of the Great East Japan Earthquake (2013)
  • Author(s): Nishi N、Yoshimura E、Ishikawa-Takata K、Tsuboyama-Kasaoka N、Kubota T、Miyachi M、Tokudome S、Yokoyama Y、Sakata K、Kobayashi S、Ogawa A
  • Journal Title: J Epidemiol Volume: 23(5) Pages: 376-381
  • Peer Reviewed
• [Journal Article] Systematic classification of evidence for dietary reference intakes for Japanese 2010 (DRIs-J 2010) in adults and future prospects of DRIs in Asian countries (2013)
  • Author(s): Nakade M、Imai E、T.Utsugi M、Tsuboyama-Kasaoka N、Takimoto H
  • Journal Title: Asia Pacific J Clin Nutr Volume: 22(4) Pages: 474-489
  • Peer Reviewed
• [Journal Article] Dietary intake of nutrients with Adequate Intake values in the Dietary Reference Intakes for Japanese (2013)
  • Author(s): Tsuboyama-Kasaoka N、Takizawa A、T.Utsugi M、Nakade M、Imai E、Kondo A、Yoshida K、Okuda N、Nishi N、Takimoto H
  • Journal Title: J Nutr Sci Vitaminol Volume: 59(6) Pages: 584-595
  • Peer Reviewed
• [Journal Article] Historical overview of the establishment of Dietary Reference Intakes for Japanese, (2013)
  • Author(s): Nobuyo Tsuboyama-Kasaoka, Megumi Tsubota-Utsugi, Eri Imai, Makiko Nakade, Masato Kasuga,
  • Journal Title: J Nutr Sci Vitaminol Supplement Volume: 59
• [Journal Article] Dietary reference intakes for Japanese 2010: Carbohydrates, (2013)
  • Author(s): Kazuhiko Yamada, Nobuyo Tsuboyama-Kasaoka, Toshinao Goda, Kyoko Saito, Toshikazu Yamanouchi, Tetsuji Yokoyama, Osamu Chonan, Eri Imai, Makiko Nakade, Seiichiro Aoe,
  • Journal Title: J Nutr Sci Vitaminol Supplement Volume: 59
• [Journal Article] 新たに発生した食品の安全性問題において参照される情報源に関する調査－エコナ油を事例として－ (2012)
  • Author(s): 吉本弥生, 笠岡（坪山）宜代, 山口亨,桂木能久,梅垣敬三,
  • Journal Title: 日本栄養士会雑誌 Volume: 55(9) Pages: 732-741
• [Journal Article] School-based "Shokuiku" program in Japan: application to nutrition education in Asian countries (2012)
  • Author(s): Miyoshi M、Tsuboyama-Kasaoka N、Nishi N
  • Journal Title: Asia Pacific Journal of Clinical Nutrition Volume: 21 Pages: 159-162
• [Presentation] 肥満とタウリン (2015)
  • Author(s): 笠岡(坪山)宜代
  • Organizer: 第一回国際タウリン研究会 日本部会 シンポジウム
  • Place of Presentation: 神戸市
  • Year and Date: 2015-02-22
  • Invited
• [Presentation] 児童における血清含硫アミノ酸濃度と身体計測値との関連 (2014)
  • Author(s): 米山ひかる、細川優、笠岡(坪山)宜代、斉藤恵美子、瀧沢あす香、原光彦
  • Organizer: 日本栄養改善学会
  • Place of Presentation: 横浜
  • Year and Date: 2014-08-20 – 2014-08-22
• [Presentation] Nutritional status of children and their mothers, and its determinants in Port Moresby, Papua New Guinea, (2011)
  • Author(s): Miyoshi M、Tsuboyama-Kasaoka N、Nishi N、Job Hawap、Tadatoshi Kuratsuji
  • Organizer: XI Asian Congress of Nutrition
  • Place of Presentation: singapore
• [Presentation] ダイエタリーサプリメントおよびいわゆる健康食品等に関連したリスク情報の諸外国での発信状況に関する研究 (2011)
  • Author(s): 笠岡(坪山)宜代、中西朋子、佐藤陽子、瀧沢あす香、石見佳子、梅垣敬三、芝池伸彰
  • Organizer: 第65回日本栄養食糧学会
  • Place of Presentation: 東京
• [Presentation] A Group Interview about Meal Services during Disaster at Nursery School in a Metropolitan Area
  • Author(s): Yukiko Amitani、Noriko Sudo、Tsuboyama-Kasaoka N、Fumiko Ishikawa、Kazuko Sako
  • Organizer: 8th Asia Pacific Conference on Clinical Nutrition
  • Place of Presentation: Maihama
  • Invited
• [Presentation] Dose-dependent Effect Of Taurine Supplementation On Obesity And Hyperleptinemia In Mice
  • Author(s): Tsuboyama-Kasaoka N、Hosokawa Y
  • Organizer: 12th International Congress on Obesity
  • Place of Presentation: Kuala Lumpur
• [Presentation] アミノ酸の機能 ～タウリンを中心として～
  • Author(s): 笠岡(坪山)宜代
  • Organizer: 日本臨床栄養学会サプリメントフォーラム
  • Place of Presentation: 京都
  • Invited
• [Presentation] 肥満・メタボリックシンドローム改善を目指した実食型フードモデルの有効性の検討
  • Author(s): 瀧沢あす香、笠岡(坪山)宜代、西信雄、細川裕子、佐々木敏、岡純
  • Organizer: 第60回日本栄養改善学会
  • Place of Presentation: 神戸
• [Presentation] What factors were important for dietary improvement after the Great East Japan Earthquake?
  • Author(s): Tsuboyama-Kasaoka N、Kazuko Sako
  • Organizer: 8th Asia Pacific Conference on Clinical Nutrition
  • Place of Presentation: Maihama
  • Invited
• [Presentation] Internet Computersystem by using linear programming for optimum community nutrition, lowcost food combination and recipe to support the dietitian activities on nutritional survey of the Great East Japan Earthquake Disaster
  • Author(s): masatoshi kajimoto, Nobuyo Tsuboyama-Kasaoka,
  • Organizer: International Congress of Nutrition,
  • Place of Presentation: Australia
• [Presentation] The differencesof anthropometric and biological indicatorsby age and sexin healthy Japanese adults
  • Author(s): Eri Imai, Megumi Tsubota-Utsugi, Makiko Nakade, NobuyoTsuboyama-Kasaoka,
  • Organizer: 第59回日本栄養改善学会
  • Place of Presentation: 名古屋
• [Presentation] 食品情報の情報源に関する消費者調査
  • Author(s): 吉本弥生、笠岡(坪山)宜代、山口亨、桂木能久、梅垣敬三、
  • Organizer: 第59回日本栄養改善学会
  • Place of Presentation: 9名古屋
• [Presentation] 食品情報の情報源に関する調査
  • Author(s): 吉本弥生1）、笠岡(坪山)宜代2）、山口亨1）、桂木能久1）、梅垣敬三
  • Organizer: 第71回公衆衛生学会
  • Place of Presentation: 山口
• [Book] 同文書院 (2013)
  • Author(s): 笠岡(坪山）宜代
  • Total Pages: 2
  • Publisher: 田中平三、中村丁次編著日本栄養学教育学会監修 栄養学概論Capter06管理栄養士・栄養士と栄養実践活動の実際「世界の管理栄養士・栄養士」
• [Book] 日本臨床栄養協会編 NR･SAテキスト 「第４章 人間栄養学」 (2013)
  • Author(s): 高田和子・笠岡(坪山）宜代
  • Total Pages: 17
  • Publisher: 第一出版
• [Book] 「第13章 遺伝子と栄養現象」小林修平・山本 茂 編集 人体栄養学の基礎、第二版 (2012)
  • Author(s): 笠岡(坪山）宜代
  • Total Pages: 6
  • Publisher: 建帛社
• [Book] 「Step3. 栄養介入」. 日本栄養士会編 国際標準化のための栄養ケアプロセス用語マニュアル (2012)
  • Author(s): 笠岡(坪山）宜代
  • Total Pages: 1
  • Publisher: 第一出版社
• [Book] 脂肪をためない4大食材&「いい油」の選び方・使い方 DHA・EPAが脂質を燃やす!筋肉アップにも効果40代からは魚をとろう! (2011)
  • Author(s): 笠岡(坪山)宜代
  • Total Pages: 2
  • Publisher: 日経ヘルスプルミエ
• [Book] Nブックス 三訂 応用栄養学 (日本人の食事摂取基準) (2011)
  • Author(s): 笠岡(坪山)宜代
  • Total Pages: 21
  • Publisher: 建帛社
• [Book] 建帛社 (2011)
  • Author(s): 森田明美、笠岡(坪山)宜代、田中清、上西一弘
  • Total Pages: 172
  • Publisher: ポケット食事摂取基準 現場ですぐに役立つ「日本人の食事摂取基準（2010年版）」