| Project/Area Number |
23617042
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
TAKAHASHI Mayumi 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (50133632)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMIZU Takahiko 千葉大学, 医学(系)研究科(研究院), その他 (40301791)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 寿命 / 老化 / コエンザイムQ / ミトコンドリア / 代謝 / 脳 / 骨格筋 / トランスジェニックマウス / クロック-1遺伝子 / ミトコンドリア機能低下 / 酸素消費量 / コエンザイムＱ / 老化機構 / 酸素消費 / マウス |
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| Outline of Final Research Achievements |
Coenzyme Q (CoQ) is one of the dietary supplements and used in expectation of the anti-aging effects. However, its effects remain to be fully validated scientifically. Therefore, we here explored its anti-aging effects by the use of aging mice. We found that the mitochondrial function in the brains of mice declined during aging compared with younger mice. In addition, the reduced brain mitochondrial function in aged mice was rescued by exogenous administration of water-soluble CoQ10 through drinking water. Regarding the effects on lifespan, transgenic mice of the clk-1 gene, which encodes one of biosynthetic enzymes of CoQ, exhibited longer lifespan, smaller bodies, and lower metabolism than those of wild-type mice, which clearly suggest that clk-1 relates to the lifespan in mammals through the regulation of mitochondrial function.
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