| Project/Area Number |
23618006
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Regenerative medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KORIYAMA Yoshiki 鈴鹿医療科学大学, 薬学部, 准教授 (70397199)
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| Co-Investigator(Renkei-kenkyūsha) |
KATO Satoru 金沢大学, 医学系, 教授 (10019614)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | Factor XIII-A / retina / optic nerve / regeneration / neurite sprouting / neurite outgrowth / nerurite sprouting / fish / mouse / zebrafish / axonal elongation / transglutaminase / CNS regeneration |
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| Outline of Final Research Achievements |
Unlike mammals, fish retinal ganglion cells have the capacity to repair their axons even after optic nerve transection. In the process of fish optic nerve regeneration, a large number of genes have been described as regeneration-associated molecules. Using molecular cloning techniques, we identified some cDNA clones belonging to the transglutaminase (TG) family as upregulation genes, and one of those was Factor XIII A subunit (FXIII-A). FXIII-A is quickly activated after optic nerve lesion and deeply involved in wound healing and optic nerve regeneration.
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