| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
Tissue engineered(TE) islets were reconstructed from dissociated islet cells originated from transgenic mice that expressed green fluorescence protein in mouse insulin promoter area. Although the reconstructive ratio of islets number was improved from 30% to 68%, it was not exceeded as primary number of native islets from one mouse. However, it was surprised that the content of insulin protein per DNA ratio was increased two fold up in TE islets.
Continuously, diabetic mice were transplanted TE islets under kidney capsule. TE islets ameliorated blood glucose levels using half number of islet cells to compare with native islets.
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