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Sugar Chain Computer-Analyzing Computational Power of the 3rdBiological Chain Material

Research Project

Project/Area Number 23650069
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Intelligent informatics
Research InstitutionTokyo Institute of Technology

Principal Investigator

YAMAMURA Masayuki  東京工業大学, 大学院・総合理工学研究科, 教授 (00220442)

Co-Investigator(Renkei-kenkyūsha) SUZUKI Yasuhiro  名古屋大学, 情報文化学部, 准教授 (50292983)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords知能情報処理 / 人工化学 / 糖鎖計算 / 文脈自由言語 / 糖鎖 / 糖転移酵素 / ゴルジ装置 / 生体分子計算 / 形式システム / 確率過程
Research Abstract

Sugar chain is called the third biological chain material which follows nucleotide and protein. It has important function such as an identifier of a cell for example. Sugar chain has unique tree structure while nucleotide and protein has linear form and is synthesized by unique process of multiple stages without any templates. We regard sugar chain formation as an information processing and analyzed its competence. Firstly, we made a simulator for sugar chain formation with stochastic artificial chemistry. Then, we tried to generate cellular identifier patterns with three stage process simulation. As the result, sugar chain formation can accept any context free language, and three separate stages are critical to generate a certain cellular identifier pattern efficiently.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (13 results)

All 2013 2012 2011 Other

All Journal Article (12 results) (of which Peer Reviewed: 6 results) Presentation (1 results)

  • [Journal Article] Harness the Nature for Computation,Natural Computing and Beyond2013

    • Author(s)
      Y.Suzuki
    • Journal Title

      Springer Verlag

      Volume: vol.6 Pages: 47-70

    • Related Report
      2012 Final Research Report
  • [Journal Article] Design and Control of Synthetic Biological Systems2013

    • Author(s)
      Ryoji Sekine and Masayuki Yamamura
    • Journal Title

      Natural Computing and Beyond

      Volume: vol.6 Pages: 104-114

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 周波数特性を用いた振動する人工遺伝子回路の自動設計2013

    • Author(s)
      林孝文、山村雅幸
    • Journal Title

      計測自動制御学会第40回知能システムシンポジウム資料集

      Pages: 211-216

    • Related Report
      2012 Final Research Report
  • [Journal Article] Design and Control of Synthetic Biological Systems2013

    • Author(s)
      Ryoji Sekine
    • Journal Title

      Natural Computing and Beyond

      Volume: 6 Pages: 104-114

    • DOI

      10.1007/978-4-431-54394-7_9

    • ISBN
      9784431543930, 9784431543947
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 周波数特性を用いた振動する人工遺伝子回路の自動設計2013

    • Author(s)
      林孝文
    • Journal Title

      計測自動制御学会第40回知能システムシンポジウム資料集

      Volume: - Pages: 211-216

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Harness the Nature for Computation2013

    • Author(s)
      Yasuhiro Suzuki
    • Journal Title

      Proceedings in Information and Communications Technology

      Volume: 6 Pages: 49-70

    • DOI

      10.1007/978-4-431-54394-7_5

    • ISBN
      9784431543930, 9784431543947
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design strategy for an initial state-independent diversity generator2012

    • Author(s)
      Ryoji Sekine, Daisuke Kiga, and Masayuki Yamamura
    • Journal Title

      Chem-Bio Informatics Journal

      Volume: vol.12 Pages: 39-49

    • NAID

      130004138125

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tunability of the ratio of cell states after the synthetic diversification by the diversity generator2012

    • Author(s)
      Ryoji Sekine,Masayuki Yamamura,Masami Hagiya,and Daisuke Kiga
    • Journal Title

      Communicative and Integrative Biology

      Volume: vol.5,no.4

    • Related Report
      2012 Final Research Report
  • [Journal Article] Behaviors of Chemical Reactions with Small Number of Molecules, Lecture Notes in Computer Science2012

    • Author(s)
      Y. Suzuki
    • Journal Title

      Springer Verlag

      Volume: vol.5777 Pages: 394-401

    • Related Report
      2012 Final Research Report
  • [Journal Article] Design strategy for an initial state-independent diversity generator2012

    • Author(s)
      Ryoji Sekine
    • Journal Title

      Chem-Bio Informatics Journal

      Volume: vol. 12 Pages: 39-49

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Behaviors of Chemical Reactions with Small Number of Molecules2012

    • Author(s)
      Y. Suzuki
    • Journal Title

      Lecture Notes in Computer Science

      Volume: vol. 5777 Pages: 394-401

    • DOI

      10.1007/978-3-642-21283-3_49

    • ISBN
      9783642212826, 9783642212833
    • Related Report
      2012 Annual Research Report
  • [Journal Article] Tunable synthetic phenotypic diversification on Waddington's landscape through autonomous signaling2011

    • Author(s)
      Sekine, R., Yamamura, M., Ayukawa, S., Ishimatsu, K., Akama, S., Takinoue, M., Hagiya, M., Kiga, D.
    • Journal Title

      Proc.Natl.Acad.Sci.U.S.A.

      Volume: 108 Issue: 44 Pages: 17969-17973

    • DOI

      10.1073/pnas.1105901108

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Sugar Computing - Computational modeling of the construction process of sugar chains by using artificial chemistry -

    • Author(s)
      Masayuki YAMAMURA
    • Organizer
      6th International Workshop on Natural Computing (IWNC6)
    • Place of Presentation
      山上会館(東大・本郷)
    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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