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Exploration of Fundamental Principle of Robustness and Adaptability of Biological Functional Systems

Research Project

Project/Area Number 23650115
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Sensitivity informatics/Soft computing
Research InstitutionHokkaido University

Principal Investigator

KOMATSUZAKI Tamiki  北海道大学, 電子科学研究所, 教授 (30270549)

Project Period (FY) 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsカオス / 生物物理 / ネットワーク / 情報数理 / 複雑系 / 情報理論 / 一分子解析 / 連結情報量 / 多変量解析 / 蛍光共鳴エネルギー移動 / 階層的ネットワーク
Research Abstract

To unveil the question of "how can complex systems adapt to the environmental changes and provide functions robustly in a thermal fluctuating world" on the basis of novel data-driven approach, two novel methods are developed : The one can extract the underlying physical quantity from a noisy single molecule time series whose noise is represented in terms of any probability distribution function, and the other can quantify higher order correlation among multivariate variables and identify irreducible information theoretic modular structure. We showed that the most conventionally used data analysis for single molecule biophysics(enzymatic reactions) led us to a physically incorrect interpretation.

Report

(2 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (24 results)

All 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (14 results) Remarks (6 results)

  • [Journal Article] Dynamic Disorder in Single Enzyme Experiments : Facts and Artifacts2011

    • Author(s)
      Tatyana Terentyeva, Hans Engelkamp, Alan Rowan, Tamiki Komatsuzaki, Johan Hofkens, Chun Biu Li, Kerstin Blank
    • Journal Title

      ACS Nano

      Volume: 6(1) Pages: 346-354

    • NAID

      120005158910

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decomposability of Multivariate Interactions2011

    • Author(s)
      Naoki Miyagawa, Hiroshi Teramoto, Chun-Biu Li and Tamiki Komatsuzaki
    • Journal Title

      Complex Systems

      Volume: 20 Pages: 165-179

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spatial Heterogeneity of Multivariate Dependence2011

    • Author(s)
      Naoki Miyagawa, Hiroshi Teramoto, Chun-Biu Li and Tamiki Komatsuzaki
    • Journal Title

      AIP Conference Proceedings "International Conference of Numerical Analysis and Applied Mathematics 2011"

      Volume: 1389 Pages: 991-991

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spatial Heterogeneity of Multivariate Dependence2011

    • Author(s)
      Naoki Miyagawa, Hiroshi Teramoto, Chun-Biu Li, Tamiki Komatsuzaki
    • Journal Title

      AIP Conference Proceedings

      Volume: 1389 Issue: 12 Pages: 991-994

    • DOI

      10.1063/1.363777

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 大域的パターンの連結情報量とその分解可能性2012

    • Author(s)
      宮川尚紀, 寺本央, 李振風, 小松崎民樹
    • Organizer
      日本物理学会第67回年次大会
    • Place of Presentation
      関西学院大学西宮上ケ原キャンパス(兵庫県)
    • Year and Date
      2012-03-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 大域的パターンの連結情報量とその分解可能性2012

    • Author(s)
      宮川尚紀, 寺本央, 李振風, 小松崎民樹
    • Organizer
      日本物理学会第67回年次大会
    • Place of Presentation
      関西学院大学西宮上ケ原キャンパス(兵庫県)(一般、口頭)
    • Year and Date
      2012-03-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 1分子実験を読み解くための新しい実践型分子理論を目指して2012

    • Author(s)
      小松崎民樹
    • Organizer
      日本化学会第92春季年会"第2次先端ウォッチング高次分子システムのための分子科学:実験と理論の挑戦"
    • Place of Presentation
      慶応大学(神奈川県)
    • Year and Date
      2012-03-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 1分子実験を読み解くための新しい実践型分子理論を目指して2012

    • Author(s)
      小松崎民樹
    • Organizer
      日本化学会第92春季年会"第2次先端ウォッチング高次分子システムのための分子科学:実験と理論の挑戦"
    • Place of Presentation
      慶応大学(神奈川県)(口頭)(招待講演)
    • Year and Date
      2012-03-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 階層構造をつくる多変数確率過程の数理2011

    • Author(s)
      宮川尚紀, 寺本央, 李振風, 小松崎民樹
    • Organizer
      分子科学討論会(札幌) 2011
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2011-09-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 階層構造をつくる多変数確率過程の数理2011

    • Author(s)
      宮川尚紀, 寺本央, 李振風, 小松崎民樹
    • Organizer
      分子科学討論会(札幌)2011
    • Place of Presentation
      札幌コンベンションセンター(札幌市)(一般、ポスター)
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] "Mining "an effective Energy landscape of a protein from single molecule time series Telluride Workshop on Protein Dynamics2011

    • Author(s)
      T. Komatsuzaki
    • Organizer
      Telluride Intermediate School(USA)
    • Place of Presentation
      Telluride Intermediate School(USA)
    • Year and Date
      2011-08-01
    • Related Report
      2011 Final Research Report
  • [Presentation] "Mining" an effective Energy landscape of a protein from single molecule time series2011

    • Author(s)
      T.Komatsuzaki
    • Organizer
      Telluride Workshop on Protein Dynamics
    • Place of Presentation
      Telluride Intermediate School (USA)(口頭)(招待講演)
    • Year and Date
      2011-08-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] How can we "mine" effective energy landscapes of proteins from single molecule time series in the violation of local equilibrium and detailed balance?2011

    • Author(s)
      T. Komatsuzaki
    • Organizer
      Telluride Workshop on Exploring energy landscapes, from single molecules to mesoscopic models
    • Place of Presentation
      Telluride Intermediate School(USA)
    • Year and Date
      2011-07-25
    • Related Report
      2011 Final Research Report
  • [Presentation] How can we "mine" effective energy landscapes of proteins from single molecule time series in the violation of local equilibrium and detailed balance?2011

    • Author(s)
      T.Komatsuzaki
    • Organizer
      Telluride Workshop on Exploring energy landscapes, from single molecules to mesoscopic models
    • Place of Presentation
      Telluride Intermediate School (USA)(口頭)(招待講演)
    • Year and Date
      2011-07-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] "Digging "single molecule time series to" mine "the underlying effective energy landscape"2011

    • Author(s)
      T. Komatsuzaki
    • Organizer
      Telluride Workshop on Single Molecule Dynamics
    • Place of Presentation
      Telluride Intermediate School(USA)
    • Year and Date
      2011-06-27
    • Related Report
      2011 Final Research Report
  • [Presentation] "Digging" single molecule time series to "mine" the underlying effective energy landscape2011

    • Author(s)
      T.Komatsuzak
    • Organizer
      Telluride Workshop on Single Molecule Dynamics
    • Place of Presentation
      Telluride Intermediate School (USA)(口頭)(招待講演)
    • Year and Date
      2011-06-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mining State Space Network from Single-Molecule Time Series2011

    • Author(s)
      T. Komatsuzaki
    • Organizer
      Telluride Workshop on Complexity of Kinetics and Dynamics in Many Dimension
    • Place of Presentation
      Telluride Intermediate School(USA)
    • Year and Date
      2011-06-20
    • Related Report
      2011 Final Research Report
  • [Presentation] Mining Energy Landscapes from Single-Molecule Time Series2011

    • Author(s)
      T.Komatsuzak
    • Organizer
      Telluride Workshop on The Complexity of Dynamics and Kinetics in Many Dimensions
    • Place of Presentation
      Telluride Intermediate School (USA)(主催者、口頭)
    • Year and Date
      2011-06-20
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://pubs.acs.org/doi/pdfplus/10.1021/nn2050328

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.es.hokudai.ac.jp/result/item.html?id=18

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.hokudai.ac.jp/bureau/topics/pdf/120206_es.pdf

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://pubs.acs.org/doi/pdfplus/10.1021/nn2050328

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.es.hokudai.ac.jp/result/item.html?id=18

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.hokudai.ac.jp/bureau/topics/pdf/120206_es.pdf

    • Related Report
      2011 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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