| Project/Area Number |
23650136
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cognitive science
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | 脳認知科学 / ゲノム脳科学 / エピジェネティクス / 認知 / 知能 / 精神発達遅滞 / CNV / マイクロアレイ |
|---|
| Research Abstract |
We divided the inbred mice into high and low performance groups by behavioral analysis, and we identified some gene sets that showed differential expression between the groups. Using monozygotic twins discordant for IQ scores, we also identified some gene sets that expressed differentially between siblings and one gene that showed differential DNA methylation status. In patients with mental retardation, we detected several known duplication or deletion syndromes and unknown copy number changes, CNVs. These genes and CNVs could be associated with cognitive abilities.
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