| Project/Area Number |
23650152
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | The Institute of Physical and Chemical Research (2012)
Osaka University (2011) |
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Principal Investigator |
FURUSAWA Chikara 独立行政法人理化学研究所, 多階層生命動態研究チーム, チームリーダー (00372631)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 幹細胞 / 分化 / 数理モデル / 計算機シミュレーション / 安定性 / 細胞分化 |
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| Research Abstract |
The purpose of this study is to understand differentiation dynamics of stem cells using computational models. We screened gene regulatory networks which can generate stem cell differentiation dynamics to identify general features of the differentiation dynamics. As results, we found that stem cells generally have oscillatory expression dynamics, and also identified characteristics of regulatory networks generating such differentiation dynamics. Based on these understandings, we constructed a computational model to represent differentiation dynamics in mouse early development.
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