Modeling of cellular heterogeneity of drug resistance
| Project/Area Number |
23650154
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Bioinformatics/Life informatics
|
|---|
| Research Institution | The Institute of Physical and Chemical Research |
|---|
Principal Investigator |
OKADA Mariko 独立行政法人理化学研究所, 細胞システムモデル化研究チーム, チームリーダー (10342833)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MITOSCH Karin ドイツ財団フェロー
奇 世援 理化学研究所
湯本 範子 理化学研究所
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
岩本 一成 理化学研究所
木村 周平 鳥取大学
KHOLODENKO Boris ダブリン大学
長嶋 剛史 東北大学
井上 聡 埼玉医科大学
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 細胞不均一性 / シグナル伝達 / 乳がん / エストロゲン受容体 / 細胞ネットワーク / 数理モデル / 単一細胞計測 |
|---|
| Research Abstract |
In this study, we try to investigate heterogeneic cellular response in tamoxifen-treated breast cancer cell using experimental measurement and mathematical modeling. First, we measured phosphorylation or/and protein level of 35 mediators in signaling network related to estrogen receptor. We identified dysregulated activities in EGFR, ErbB2, ErbB3 receptor, estrogen receptor, GSK3beta, E2F1, CREB, Fos, Jun, JunB in averaged cell population. Furthermore, ErbB3, ERK and Akt showed cell-to-cell variation in their activities. We constructed mathematical model of this signaling network and investigate system properties of the network that may induce heterogeneic response.
|
Report
(3 results)
Research Products
(25 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] A kinetic model explains increased gefitinib sensitivity associated with Mig6 expression2011
Author(s)
Naruo, Y., Nagashima, T., Ushikoshi-Nakayama, R., Saeki, Y., Nakakuki, T., Naka, T., Tanaka, H., Tsai, S-F., and Okada-Hatakeyama, M
-
Journal Title
BMC Systems Biology
Volume: 5(1)
Pages: 29-29
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
