An engineered cell with a simplified genetic code
| Project/Area Number |
23650155
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
KIGA Daisuke 東京工業大学, 総合理工学研究科(研究院), 准教授 (30376587)
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| Research Collaborator |
小林 晃大 東京工業大学, 大学院生
網蔵 和晃 東京工業大学, 大学院生
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 合成生物学 / 遺伝暗号 / リボソーム / ｔRNA / 直交性 / tRNA |
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| Research Abstract |
Why does life use 20 canonical amino acids? Considering general evolutionary principle where a simple form develops into a complex form, the universal 20 amino acids are not likely to be defined from the establishment of the first genetic code. In this study, we developed multiple amino acid-excluded genetic codes by extension of our previous work. We also tried construction of a simplified code in a living cell.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Simplification of the genetic code : restricted diversity of genetically encoded amino acids2012
Author(s)
Akio Kawahara-Kobayashi, Akiko Masuda, Yuhei Araiso, Yoko Sakai, Atsushi Kohda, Masahiko Uchiyama, Shun Asami, Takayoshi Matsuda, Ryuichiro Ishitani, Naoshi Dohmae, Shigeyuki Yokoyama, Takanori Kigawa, Osamu Nureki, Daisuke Kiga
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Journal Title
Nucleic Acids Research
Volume: 40(20)
Pages: 10576-84
Related Report
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[Journal Article] Simplification of the genetic code: restricted diversity of genetically encoded amino acids2012
Author(s)
Kawahara-Kobayashi A, Masuda A, Araiso Y, Sakai Y, Kohda A, Uchiyama M, Asami S, Matsuda T, Ishitani R, Dohmae N, Yokoyama S, Kigawa T, Nureki O, Kiga D
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Journal Title
Nucleic Acids Res
Volume: 40
Issue: 20
Pages: 10576-10576
DOI
Related Report
Peer Reviewed
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