How do vascular endothelial cells ameliorate white matter damage?
Project/Area Number |
23650159
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Neuroscience in general
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Research Institution | Gunma University |
Principal Investigator |
ISHIZAKI Yasuki 群馬大学, 大学院・医学系研究科, 教授 (90183003)
|
Co-Investigator(Renkei-kenkyūsha) |
SHIBASAKI Koji 群馬大学, 大学院・医学系研究科, 准教授 (20399554)
IMAI Hideaki 東京大学, 医学部附属病院, 特任講師 (70359587)
NARUSE Masae 群馬大学, 大学院・医学系研究科, 助教 (60455219)
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Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 移植・再生医療 / 神経科学 / 脳神経疾患 / 再生医学 / 細胞・組織 / 虚血 / 白質梗塞 / 内皮細胞 / オリゴデンドロサイト / 再生 / 脱随 / 前駆細胞 |
Research Abstract |
I found that transplantation of cerebral microvascular endothelial cells ameliorates white matter damage. I also found that cerebral microvascular endothelial cells stimulate proliferation of oligodendrocyte precursor cells in vitro. The conditioned medium from microvascular endothelial cell culture also stimulates proliferation of oligodendrocyte precursor cells, indicating that a humoral factor produced and released by endothelial cells acts as a mitogen for oligodendrocyte precursor cells.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Localization of acetylcholine-related molecules in the retina: implication of the communication from photoreceptor to retinal pigment epithelium2012
Author(s)
Matsumoto, H., Shibasaki, K., Uchigashima, M., Koizumi, A., Kurachi, M., Moriwaki, Y., Misawa, H., Kawashima, K., Watanabe, M., Kishi, S., Ishizaki, Y.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Brain microvascular endothelial celltransplantation ameliorates ischemic white matter damage2012
Author(s)
Puentes, S., Kurachi, M., Shibasaki, K., Naruse, M., Yoshimoto, Y., Mikuni, M., Imai, H., Ishizaki, Y.
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Journal Title
Brain Res
Volume: 1469
Pages: 43-53
Related Report
Peer Reviewed
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[Journal Article] Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine gamma-lyase, an animal model of cystathioninuria. Free Radic2012
Author(s)
Yamada, H., Akahoshi, N., Kamata, S., Hagiya, Y., Hishiki, T., Nagahata, Y., Matsuura, T., Takano, N., Mori, M., Ishizaki, Y., Izumi, T., Kumagai, Y., Kasahara, T., Suematsu, M., Ishii, I.
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Journal Title
Biol. Med
Volume: 52
Pages: 1716-1726
Related Report
Peer Reviewed
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[Journal Article] Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine gamma-lyase, an animal model of cystathioninuria.2012
Author(s)
Yamada H, Akahoshi N, Kamata S, Hagiya Y, Hishiki T, Nagahata Y, Matsuura T, Takano N, Mori M, Ishizaki Y, Izumi T, Kumagai Y, Kasahara T, Suematsu M, Ishii I
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Journal Title
Free Radic Biol Med
Volume: 52
Issue: 9
Pages: 1716-1726
DOI
Related Report
Peer Reviewed
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