| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
In mature post-mitotic neurons derived from mouse hippocampus, a hist1h3f gene, which encodes replication-dependent core histone H3.2, is expressed upon stimulation to glutamine receptors. Salt extraction and metabolic labeling of newly synthesized proteins in neurons revealed that core histone proteins are increased at protein levels in responseto glutamine receptor stimulation. These results suggest that newly synthesized replication dependent core histones play a role in post-mitotic neurons.
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