Mechanism underlying photoreceptor degeneration in response to vesicular fusion defects
Project/Area Number |
23650173
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Neuroscience in general
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Research Institution | 沖縄科学技術大学院大学 |
Principal Investigator |
MASAI Ichiro 沖縄科学技術大学院大学, 神経発生ユニット, 准教授 (50242087)
|
Co-Investigator(Renkei-kenkyūsha) |
NISHIWAKI Yuko 沖縄科学技術大学院, 神経発生ユニット, 研究員 (20360620)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 神経科学 / 脳神経疾患 / 視細胞変性 / 遺伝疾患 / アポトーシス / 小胞輸送 / ゼブラフィッシュ / BH3-only蛋白質 / 細胞死 / β-SNAP / BNip1 / BH3蛋白質 |
Research Abstract |
There are hereditary photoreceptor degeneration diseases in human. While previous studies suggested a connection between defects in vesicular transport and photoreceptor degeneration, the mechanism behind this link remained elusive. In this study, we investigated the mechanism underlying photoreceptor degeneration using zebrafish and identified BNip1 as a factor that induces cell death in response to vesicular transport defects. This finding uncovers a novel mechanism of photoreceptor degeneration and may advance our understanding of pathological process of human genetic retinal disease.
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] The BH3-only SNARE BNip1 mediates photoreceptor apoptosis in response to vesicular fusion defects2013
Author(s)
Nishiwaki, Y., Yoshizawa, A., Kojima, Y., Oguri, E., Nakamura, S., Suzuki, S., Yuasa-Kawada, J., Kinoshita-Kawada, M., Mochizuki, T., and Masai, I.
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Journal Title
Developmental Cell
Volume: 25
Issue: 4
Pages: 374-387
DOI
Related Report
Peer Reviewed
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[Presentation] Syntaxin18cis-SNARE complex is a novel alarm factorthat detects vesicular transport defects2013
Author(s)
Nishiwaki, Y., Yoshizawa, A., Kojima, Y.,Oguri, E., Nakamura, S., Suzuki, S.,Yuasa-Kawada, J., Kinoshita-Kawada, M.,Mochizuki, T., and Masai, I.
Organizer
The 46th Annual Meeting of the Japanese Society of Developmental Biologists.
Place of Presentation
Matsue, Shimane Japan
Related Report
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[Presentation] Syntaxin18 cis-SNARE complex is a novel alarm factor that detects vesicular transport defects2013
Author(s)
Nishiwaki, Y., Yoshizawa, A., Kojima, Y., Oguri, E., Nakamura, S., Suzuki, S., Yuasa-Kawada, J., Kinoshita-Kawada, M., Mochizuki, T., and Masai, I.
Organizer
The 46th Annual Meeting of the Japanese Society of Developmental Biologists
Place of Presentation
Matsue, Japan
Related Report
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[Presentation] Geneticmutation of beta-SNAP causes photoreceptordegeneration through the activation of theBH3-only SNARE, BNip12012
Author(s)
Nishiwaki, Y., Yoshizawa, A., Kojima, Y.,Oguri, E., Nakamura, S., Suzuki, S.,Yuasa-Kawada, J., Kinoshita-Kawada, M.,Mochizuki, T., and Masai, I.
Organizer
10th International Conference Zebrafish Development and Genetics
Place of Presentation
Madison, USA
Related Report
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[Presentation] Genetic mutation of beta-SNAP causes photoreceptor degeneration through the activation of the BH3-only SNARE, BNip12012
Author(s)
Nishiwaki, Y., Yoshizawa, A., Kojima, Y.,Oguri, E., Nakamura, S., Suzuki, S.,Yuasa-Kawada, J., Kinoshita-Kawada, M.,Mochizuki, T., and Masai, I.
Organizer
APDBC Taiwan 2012 Asia-Pacific Developmental Biology Conference 2012
Place of Presentation
Taipei Innovation City Convention Center, Taipei, Taiwan
Related Report
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[Presentation] The BH3-only SNARE of syntaxin18, BNip1, mediates photoreceptor apoptosis in response to vesicular fusion defects2012
Author(s)
Nishiwaki, Y., Yoshizawa, A., Kojima, Y.,Oguri, E., Nakamura, S., Suzuki, S.,Yuasa-Kawada, J., Kinoshita-Kawada, M.,Mochizuki, T., and Masai, I.
Organizer
Gordon researchconference ? visual system development.
Place of Presentation
Colby-Sawyer College, New London, NH
Related Report
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[Presentation] The BH3-onlySNARE of syntaxin18, BNip1, is a mediatorof photoreceptor apoptosis in response tovesicular fusion defects2012
Author(s)
Nishiwaki, Y., Yoshizawa, A., Kojima, Y.,Oguri, E., Nakamura, S., Suzuki, S.,Yuasa-Kawada, J., Kinoshita-Kawada, M.,Mochizuki, T., and Masai, I.
Organizer
The 35th annual meeting of the Molecular Biology Society
Place of Presentation
Japan. Fukuoka
Related Report
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[Presentation] Genetic mutation of beta-SNAP causes photoreceptor degeneration through the activation of the BH3-only SNARE,BNip12012
Author(s)
Nishiwaki, Y., Yoshizawa, A., Kojima, Y.,Oguri, E., Nakamura, S., Suzuki, S.,Yuasa-Kawada, J., Kinoshita-Kawada, M.,Mochizuki, T., and Masai, I.
Organizer
The 18th Japanese Medaka and zebrafish meeting.
Place of Presentation
Kyoto, Japan
Related Report
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[Presentation] The BH3-onlySNARE of syntaxin18, BNip1, is a mediatorof photoreceptor apoptosis in response tovesicular fusion defects2012
Author(s)
Nishiwaki, Y., Yoshizawa, A., Kojima, Y.,Oguri, E., Nakamura, S., Suzuki, S.,Yuasa-Kawada, J., Kinoshita-Kawada, M.,Mochizuki, T., and Masai, I.
Organizer
Neuroscience 2012.The 35thannual meeting of the JapanNeuroscience Society.
Place of Presentation
Nagoya, Japan
Related Report
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[Presentation] Geneticmutation of beta-SNAP causesphotoreceptor degeneration through theactivation of the BH3-only SNARE, BNip12012
Author(s)
Nishiwaki, Y., Yoshizawa, A., Kojima, Y.,Oguri, E., Nakamura, S., Suzuki, S.,Yuasa-Kawada, J., Kinoshita-Kawada, M.,Mochizuki, T., and Masai, I.
Organizer
Joint meeting of the 45th annual meeting of the Japanese society of DevelopmentalBiologists & the 64thannual meeting of theJapanese society of Cell Biology.
Place of Presentation
Kobe,Japan
Related Report
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[Presentation] Genetic mutation of beta-SNAP causes photoreceptor degeneration through the activation of the BH3-only SNARE, BNip12012
Author(s)
Nishiwaki, Y., Yoshizawa, A., Kojima, Y., Oguri, E., Nakamura, S., Suzuki, S., Yuasa-Kawada, J., Kinoshita-Kawada, M., Mochizuki, T., and Masai, I.
Organizer
10th International Conference Zebrafish Development and Genetics
Place of Presentation
Madison, USA
Related Report
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[Presentation] Genetic mutation of beta-SNAP causes photoreceptor degeneration through the activation of the BH3-only SNARE, BNip12012
Author(s)
Nishiwaki, Y., Yoshizawa, A., Kojima, Y., Oguri, E., Nakamura, S., Suzuki, S., Yuasa-Kawada, J., Kinoshita-Kawada, M., Mochizuki, T., and Masai, I.
Organizer
APDBC Taiwan 2012 Asia-Pacific Developmental Biology Conference 2012
Place of Presentation
Taipei, Taiwan
Related Report
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[Presentation] The BH3-only SNARE of syntaxin18, BNip1, mediates photoreceptor apoptosis in response to vesicular fusion defects2012
Author(s)
Nishiwaki, Y., Yoshizawa, A., Kojima, Y., Oguri, E., Nakamura, S., Suzuki, S., Yuasa-Kawada, J., Kinoshita-Kawada, M., Mochizuki, T., and Masai, I.
Organizer
Gordon research conference visual system development
Place of Presentation
New London, USA
Related Report
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[Presentation] The BH3-only SNARE of syntaxin18, BNip1, is a mediator of photoreceptor apoptosis in response to vesicular fusion defects2012
Author(s)
Nishiwaki, Y., Yoshizawa, A., Kojima, Y., Oguri, E., Nakamura, S., Suzuki, S., Yuasa-Kawada, J., Kinoshita-Kawada, M., Mochizuki, T., and Masai, I.
Organizer
The 35th annual meeting of the Molecular Biology Society of Japan
Place of Presentation
Fukuoka, Japan
Related Report
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[Presentation] Genetic mutation of beta-SNAP causes photoreceptor degeneration through the activation of the BH3-only SNARE, BNip12012
Author(s)
Nishiwaki, Y., Yoshizawa, A., Kojima, Y., Oguri, E., Nakamura, S., Suzuki, S., Yuasa-Kawada, J., Kinoshita-Kawada, M., Mochizuki, T., and Masai, I.
Organizer
The 18th Japanese Medaka and zebrafish meeting
Place of Presentation
Kyoto, Japan
Related Report
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[Presentation] The BH3-only SNARE of syntaxin18, BNip1, is a mediator of photoreceptor apoptosis in response to vesicular fusion defects2012
Author(s)
Nishiwaki, Y., Yoshizawa, A., Kojima, Y., Oguri, E., Nakamura, S., Suzuki, S., Yuasa-Kawada, J., Kinoshita-Kawada, M., Mochizuki, T., and Masai, I.
Organizer
The 35th annual meeting of the Japan Neuroscience Society
Place of Presentation
Nagoya, Japan
Related Report
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[Presentation] Genetic mutation of beta-SNAP causes photoreceptor degeneration through the activation of the BH3-only SNARE, BNip12012
Author(s)
Nishiwaki, Y., Yoshizawa, A., Kojima, Y., Oguri, E., Nakamura, S., Suzuki, S., Yuasa-Kawada, J., Kinoshita-Kawada, M., Mochizuki, T., and Masai, I.
Organizer
Joint meeting of the 45th annual meeting of the Japanese society of Developmental Biologists & the 64th annual meeting of the Japanese society of Cell Biology
Place of Presentation
Kobe, Japan
Related Report
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[Presentation] Mutation of beta-SNAP induces amitochondria-dependent apoptosis inzebrafish photoreceptors2011
Author(s)
Nishiwaki, Y., Suzuki, S., Yoshizawa, A.,Kojima, Y., Mochizuki, T., Masai, I.
Organizer
7th EuropeanZebrafish Meeting
Place of Presentation
Edinburgh, Scotland
Related Report
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[Presentation] Azebrafish corona mutation induces aBcl2-dependent apoptosis in photoreceptor2011
Author(s)
Nishiwaki, Y., Suzuki, S., Yoshizawa, A.,Kojima, Y., Mochizuki, T., Masai, I.
Organizer
44th Annual Meeting of the Japanese Society of Developmental Biologists
Place of Presentation
Okinawa Convention Center (Ginowan City)
Related Report
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