The expression system specific for the circadian center
| Project/Area Number |
23650177
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Hiroshima University |
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Principal Investigator |
TAKUMI Toru 広島大学, 大学院・医歯薬保健学研究院, 教授 (00222092)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 遺伝子 / 細胞・組織 / 行動学 / 神経科学 |
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| Research Abstract |
The mammalian oscillator for circadian rhythm with a period of 24 hours is localized in the suprachiasmatic nucleus (SCN). Although the recent advance in genetic engineering methods provide different region-specific expression system, we have not obtained the specific expression system in SCN. The present study is to try to establish a system of SCN-specific expression using a combination of different promoters.
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Report
(3 results)
Research Products
(26 results)
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[Journal Article] Period coding of Bmal1 oscillators in the suprachiasmatic nucleus2012
Author(s)
Myung, J., Hong, S., Hatanaka, F., Nakajima, Y., De Schutter, E. and Takumi, T
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Journal Title
J. Neurosci
Volume: 32
Pages: 8900-8918
Related Report
Peer Reviewed
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[Journal Article] Differential patterns in the periodicity and dynamics of clock gene expression in mouse liver and stomach2012
Author(s)
Mazzoccoli, G., Francavilla, M., Pazienza, V., Piepoli, A., Benegiamo, G., Vinciguerra, M, Giuliani, F., Yamamoto, T. and Takumi, T
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Journal Title
Chronobiol. Int
Volume: 29
Pages: 1300-1311
Related Report
Peer Reviewed
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[Journal Article] REV -ERBa and the clock gene machinery in mouse peripheral tissues: a possible role as a synchronizing hing2012
Author(s)
Mazzoccoli, G., Cai, Y., Liu, M., Francavilla, M., Giuliani, F., Piepoli, A., Pazienza, V., Vinciguerra, M, Yamamoto, T. and Takumi, T
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Journal Title
J. Biol. Regul. Homeost. Agents
Volume: 26
Pages: 265-276
Related Report
Peer Reviewed
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[Presentation] Genome-wide profiling of the core clock protein BMAL1 targets reveals strict relationship with metabolism2011
Author(s)
Fumiyuki Hatanaka, Chiaki Matsubara, Jihwan Myung, Takashi Yoritaka, Naoko Uemura, Shuichi Tsutsumi, Akinori Kanai, Yutaka Suzuki, Hiroyuki Aburatani, Sumio Sugano, Toru Takumi
Organizer
第34回日本神経科学大会
Place of Presentation
横浜
Related Report
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