The expression system specific for the circadian center

• Project/Area Number: 23650177
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Hiroshima University
• Principal Investigator: TAKUMI Toru 広島大学, 大学院・医歯薬保健学研究院, 教授 (00222092)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 遺伝子 / 細胞・組織 / 行動学 / 神経科学

Research Abstract

The mammalian oscillator for circadian rhythm with a period of 24 hours is localized in the suprachiasmatic nucleus (SCN). Although the recent advance in genetic engineering methods provide different region-specific expression system, we have not obtained the specific expression system in SCN. The present study is to try to establish a system of SCN-specific expression using a combination of different promoters.

Research Products

• [Journal Article] Characterization and modeling of intermittent locomotor dynamics in clock-deficient mice (2013)
  • Author(s): Nakamura, T., Takumi, T., Takano, A., Hatanaka, F. and Yamamoto, Y
  • Journal Title: PLoS ONE Volume: 8
  • Peer Reviewed
• [Journal Article] Characterization and modeling of intermittent locomotor dynamics in clock gene-deficient mice (2013)
  • Author(s): T. Nakamura, T. Takumi, A. Takano, F. Hatanaka, Y. Yamamoto
  • Journal Title: PLoS ONE Volume: 8(3) Issue: 3 Pages: e58884-e58884
  • DOI: 10.1371/journal.pone.0058884
  • Peer Reviewed
• [Journal Article] Period coding of Bmal1 oscillators in the suprachiasmatic nucleus (2012)
  • Author(s): Myung, J., Hong, S., Hatanaka, F., Nakajima, Y., De Schutter, E. and Takumi, T
  • Journal Title: J. Neurosci Volume: 32 Pages: 8900-8918
  • Peer Reviewed
• [Journal Article] Differential patterns in the periodicity and dynamics of clock gene expression in mouse liver and stomach (2012)
  • Author(s): Mazzoccoli, G., Francavilla, M., Pazienza, V., Piepoli, A., Benegiamo, G., Vinciguerra, M, Giuliani, F., Yamamoto, T. and Takumi, T
  • Journal Title: Chronobiol. Int Volume: 29 Pages: 1300-1311
  • Peer Reviewed
• [Journal Article] REV -ERBa and the clock gene machinery in mouse peripheral tissues: a possible role as a synchronizing hing (2012)
  • Author(s): Mazzoccoli, G., Cai, Y., Liu, M., Francavilla, M., Giuliani, F., Piepoli, A., Pazienza, V., Vinciguerra, M, Yamamoto, T. and Takumi, T
  • Journal Title: J. Biol. Regul. Homeost. Agents Volume: 26 Pages: 265-276
  • Peer Reviewed
• [Journal Article] Period coding of Bmal1 oscillators in the suprachiasmatic nucleus. (2012)
  • Author(s): Myung J et al
  • Journal Title: J Neurosci. Volume: 32 Issue: 26 Pages: 8900-18
  • DOI: 10.1523/jneurosci.5586-11.2012
  • Peer Reviewed
• [Journal Article] REV-ERBα and the clock gene machinery in mouse peripheral tissues: a possible role as a synchronizing hinge. (2012)
  • Author(s): Mazzoccoli G et al
  • Journal Title: J Biol Regul Homeost Agents. Volume: 26 Pages: 265-76
  • Peer Reviewed
• [Journal Article] Differential patterns in the periodicity and dynamics of clock gene expression in mouse liver and stomach. (2012)
  • Author(s): Mazzoccoli G et al
  • Journal Title: Chronobiol Int. Volume: 29 Issue: 10 Pages: 1300-11
  • DOI: 10.3109/07420528.2012.728662
  • Peer Reviewed
• [Presentation] Molecular links between rhythm and mood (2012)
  • Author(s): Toru Takumi
  • Organizer: 1stSwiss Chronobiology Meeting
  • Place of Presentation: Fribourg, Switzerland
  • Year and Date: 2012-09-06
• [Presentation] 気分障害と概日時計を結ぶリチウム (2012)
  • Author(s): 内匠透
  • Organizer: 第31回リチウム研究会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-14
• [Presentation] A molecular link between mood and circadian clock (2012)
  • Author(s): Toru Takumi
  • Organizer: 第85回日本生化学会大会シンポジウム「Biochemistry of mind」
  • Place of Presentation: 福岡
• [Presentation] 概日リズムと医学研究 (2012)
  • Author(s): 内匠透
  • Organizer: 第24回日本脳循環代謝学会総会
  • Place of Presentation: 広島
• [Presentation] 時計遺伝子 Per2 と気分 (2012)
  • Author(s): 内匠透
  • Organizer: 第34回日本生物学的精神医学会シンポジウム「分子遺伝学の鍵分子からみた精神疾患」
  • Place of Presentation: 神戸
• [Presentation] リズムと気分 (2012)
  • Author(s): 内匠透
  • Organizer: 第19回日本時間生物学会学術大会シンポジウム「精神疾患の時間生物学的基盤」
  • Place of Presentation: 札幌
• [Presentation] Circadian Network of Bmal1 (2012)
  • Author(s): Toru Takumi
  • Organizer: Circadian Network of Bmal1
  • Place of Presentation: Destin, FL, USA
• [Presentation] Circadian Network of Bmal1 (2012)
  • Author(s): Toru Takumi
  • Organizer: SRBR2012
  • Place of Presentation: Destin, FL, USA
  • Invited
• [Presentation] Heterogeneity of intrinsic period as a basis of coding in the SCN (2012)
  • Author(s): J. Myung et al (T. Takumi)
  • Organizer: 第１９回日本時間生物学会学術大会
  • Place of Presentation: 札幌
• [Presentation] リズムと気分 (2012)
  • Author(s): 内匠透
  • Organizer: 第１９回日本時間生物学会学術大会
  • Place of Presentation: 札幌
  • Invited
• [Presentation] 時計遺伝子Per2と気分 (2012)
  • Author(s): 内匠透
  • Organizer: 第３４回日本生物学的精神医学会
  • Place of Presentation: 神戸
  • Invited
• [Presentation] 概日リズムと医学研究 (2012)
  • Author(s): 内匠透
  • Organizer: 第２４回日本脳循環代謝学会総会
  • Place of Presentation: 広島
  • Invited
• [Presentation] A molecular link between mood and circadian clock (2012)
  • Author(s): Toru Takumi
  • Organizer: 第８５回日本生化学会大会
  • Place of Presentation: 福岡
• [Presentation] Rhythm and the blues (2011)
  • Author(s): Toru Takumi
  • Organizer: Worldsleep 2011
  • Place of Presentation: KyotoSymposium
• [Presentation] The phosphorylation of PERIOD2 via glycogen synthase kinase 3b has the possibility of the regulator in the depression-like behavior (2011)
  • Author(s): Yousuke Yamawaki, Atsuko Takano, Toru Takumi
  • Organizer: The 32ndNaito Conference
  • Place of Presentation: Hokuto, Yamanashi
• [Presentation] Genome-wide profiling of the core clock protein BMAL1 targets reveals strict relationship with metabolism (2011)
  • Author(s): Fumiyuki Hatanaka, Chiaki Matsubara, Jihwan Myung, Takashi Yoritaka, Naoko Uemura, Shuichi Tsutsumi, Akinori Kanai, Yutaka Suzuki, Hiroyuki Aburatani, Sumio Sugano, Toru Takumi
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] 気分障害と概日時計を結ぶリチウム
  • Author(s): 内匠透
  • Organizer: 第３１回リチウム研究会
  • Place of Presentation: 東京
  • Invited
• [Presentation] Molecular links between rhythm and mood
  • Author(s): Toru Takumi
  • Organizer: 1st Swiss Chronobiology Meeting
  • Place of Presentation: Fribourg, Switzerland
  • Invited