Participation of the oligodendrocyte/oligodendrocyte precursor cell in the morbidity of schizophrenia
| Project/Area Number |
23650186
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Tohoku University |
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Principal Investigator |
OSUMI Noriko 東北大学, 大学院・医学系研究科, 教授 (00220343)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 統合失調症 / オリゴデンドロサイト前駆細胞 / オリゴ新生 / 神経新生 / プレパル ス抑制 |
|---|
| Research Abstract |
We examined relationship between defects in prepulse inhibition and OPC-genesis. Almost all OPCs expressed Fabp7, whereas about 7% of did Pax6. Significant change was not detected in OPC-genesis of Fabp7 KO mice and Pax6 mutant mice.
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Report
(3 results)
Research Products
(36 results)
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[Journal Article] A Sensitive Period for GABAergic Interneurons in the Dentate Gyrus in Modulating Sensorimotor Gating2013
Author(s)
Guo,N., Yoshizaki,K., Kimura, R., Suto, F., Yanagawa,Y. and Osumi,N.
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Journal Title
The Journal of Neuroscience
Volume: 33(15)
Pages: 6691-6704
Related Report
Peer Reviewed
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[Journal Article] Differential Proliferation Rhythm of Neural Progenitor and Oligodendrocyte Precursor Cells in the Young Adult Hippocampus2011
Author(s)
Matsumoto, Y., Tsunekawa, Y., Nomura, T., Suto, F., Matsumata, M., Tsuchiya, S., Osumi, N.
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Journal Title
PLoS ONE
Volume: 6(11)
Issue: 11
Pages: e27628-e27628
DOI
Related Report
Peer Reviewed
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