Microglial subtypes: Identification and characterization of their roles in emotional functions
| Project/Area Number |
23650190
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Nagoya University |
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Principal Investigator |
SAWADA Makoto 名古屋大学, 環境医学研究所, 教授 (10187297)
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| Co-Investigator(Renkei-kenkyūsha) |
ONO Kenji 名古屋大学, 環境医学研究所, 助教 (80329698)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | グリア細胞 / ミクログリア / サブタイプ / 精神活動 / グリア神経相関 |
|---|
| Research Abstract |
Although Hoxb8-lineage microglia are indicated to be involved in the obsessive-compulsive disorder spectrum disorder, there are few lines of evidence between microglia and emotional regulation. In this project I indicated that cloned microglia and a part of bone marrow progenitorcells expressed Hoxb8. Injection of these cells directly into striatum improved stress-vulnerability in the forced-swimming stressed mice. These results suggest that microglia may be involved in stress-regulation of higher brain functions.
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Report
(3 results)
Research Products
(57 results)
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[Journal Article] In vivo imaging of transplanted islets labeled with a novel cationic nanoparticle2013
Author(s)
Oishi K, Miyamoto Y, Saito H, Murase K, Ono K, Sawada M, Watanabe M, Noguchi Y, Fujiwara T, Hayashi S, Noguchi H
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] In vivo imaging of transplanted islets labeled with a novel cationic nanoparticle2013
Author(s)
Oishi K, Miyamoto Y, Saito H, Murase K, Ono K, Sawada M, Watanabe M, Noguchi Y, Fujiwara T, Hayashi S, Noguchi H
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Journal Title
PLOS ONE
Volume: 8(2)
Issue: 2
Pages: e57046-e57046
DOI
Related Report
Peer Reviewed
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[Journal Article] Effects of a brain-engraftable microglial cell line expressing anti-prion scFv antibodies on survival times of mice infected with scrapie prions2011
Author(s)
Fujita K, Yamaguchi Y, Mori T, Muramatsu N, Miyamoto T, Yano M, Miyata H, Ootsuyama A, Sawada M, Matsuda H, Kaji R, Sakaguchi S
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Journal Title
Cellular and Molecular Neurobiology
Volume: 31
Pages: 999-1008
Related Report
Peer Reviewed
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[Journal Article] Matrix metallo- proteinase-9 contributes to kindled seizure development in pentylene- tetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus2011
Author(s)
Mizoguchi H, Nakade J, Tachibana M, Ibi D, Someya E, Koike H, Kamei H, Nabeshima T, Itohara S, Takuma K, Sawada M, Sato J, Yamada K
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Journal Title
Journal of Neuroscience
Volume: 31
Pages: 12963-12971
Related Report
Peer Reviewed
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[Journal Article] Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus2011
Author(s)
H Mizoguchi, J Nakade, M Tachibana, D Ibi, E Someya, H Koike, H Kamei, T Nabeshima, S Itohara, K Takuma, M Sawada, J Sato, K Yamada
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Journal Title
Journal of Neuroscience
Volume: 31
Issue: 36
Pages: 12963-12971
DOI
Related Report
Peer Reviewed
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[Journal Article] Effects of a brain-engraftable microglial cell line expressing anti-prion scFv antibodies on survival times of mice infected with scrapie prions2011
Author(s)
Fujita K, Yamaguchi Y, Mori T, Muramatsu N, Miyamoto T, Yano M, Miyata H, Ootsuyama A, Sawada M, Matsuda H, Kaji R, Sakaguchi S
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Journal Title
Cell Mol Neurobiol
Volume: 31(7)
Issue: 7
Pages: 999-1008
DOI
Related Report
Peer Reviewed
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