• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Microglial subtypes: Identification and characterization of their roles in emotional functions

Research Project

Project/Area Number 23650190
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Neurochemistry/Neuropharmacology
Research InstitutionNagoya University

Principal Investigator

SAWADA Makoto  名古屋大学, 環境医学研究所, 教授 (10187297)

Co-Investigator(Renkei-kenkyūsha) ONO Kenji  名古屋大学, 環境医学研究所, 助教 (80329698)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsグリア細胞 / ミクログリア / サブタイプ / 精神活動 / グリア神経相関
Research Abstract

Although Hoxb8-lineage microglia are indicated to be involved in the obsessive-compulsive disorder spectrum disorder, there are few lines of evidence between microglia and emotional regulation. In this project I indicated that cloned microglia and a part of bone marrow progenitorcells expressed Hoxb8. Injection of these cells directly into striatum improved stress-vulnerability in the forced-swimming stressed mice. These results suggest that microglia may be involved in stress-regulation of higher brain functions.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (57 results)

All 2013 2012 2011 Other

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (30 results) (of which Invited: 4 results) Book (8 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 2 results)

  • [Journal Article] In vivo imaging of transplanted islets labeled with a novel cationic nanoparticle2013

    • Author(s)
      Oishi K, Miyamoto Y, Saito H, Murase K, Ono K, Sawada M, Watanabe M, Noguchi Y, Fujiwara T, Hayashi S, Noguchi H
    • Journal Title

      PLoS One

      Volume: 8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo imaging of transplanted islets labeled with a novel cationic nanoparticle2013

    • Author(s)
      Oishi K, Miyamoto Y, Saito H, Murase K, Ono K, Sawada M, Watanabe M, Noguchi Y, Fujiwara T, Hayashi S, Noguchi H
    • Journal Title

      PLOS ONE

      Volume: 8(2) Issue: 2 Pages: e57046-e57046

    • DOI

      10.1371/journal.pone.0057046

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel positive-charged nano- particles for efficient magnetic resonance imaging of islet transplantation2012

    • Author(s)
      Oishi K, Noguchi H, Saito H,Yukawa H, Miyamoto Y, Ono K, Murase K, Sawada M, Hayashi S
    • Journal Title

      Cell Medicine

      Volume: 3 Pages: 43-49

    • URL

      http://www.ingentaconnect.com/content/cog/cm

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hemokinin-1 gene expression is upregulated in microglia activated by lipopoly- saccharide through NFkB and p38 MAPK signaling pathways2012

    • Author(s)
      Sakai A, Takasu K, Sawada M, Suzuki H
    • Journal Title

      PLoS One

      Volume: 7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of voltage-gated proton channels by local anaesthetics in GMI-R1 rat microglia2012

    • Author(s)
      Matsuura T, Mori T, Hasaka M, Kuno M, Kawawaki J, Nishikawa K, Nakanishi T, Sawada M, Asada A
    • Journal Title

      The Journal of Physiology

      Volume: 590 Pages: 827-844

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel positive-charged nanoparticles for efficient magnetic resonance imaging of islet transplantation.2012

    • Author(s)
      Oishi K, Noguchi H, Saito H,Yukawa H, Miyamoto Y, Ono K, Murase K, Sawada M, Hayashi S
    • Journal Title

      Cell Medicine

      Volume: 3(1-3) Pages: 43-49

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of voltage-gated proton channels by local anesthetics in GMI-R1 rat microglia2012

    • Author(s)
      Tadashi Matsuura, Takashi Mori, Megumi Hasaka, Miyuki Kuno, Junko Kawawaki, Kiyonobu Nishikawa, Toshio Narahashi, Makoto Sawada, Akira Asada
    • Journal Title

      The Journal of Physiology

      Volume: 590 Issue: 4 Pages: 827-843

    • DOI

      10.1113/jphysiol.2011.218149

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hemokinin-1 gene expression is upregulated in microglia activated by lipopolysaccharide through NF-κB and p38 MAPK signaling pathways.2012

    • Author(s)
      Sakai A, Takasu K, Sawada M, Suzuki H.
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 2 Pages: e32268-e32268

    • DOI

      10.1371/journal.pone.0032268

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] New fluorescent probes targeting the mitochondrial-located translocator protein 18 kDa (TSPO) as activated microglia imaging agents2011

    • Author(s)
      Denora N, Laquintana V, Trapani A, Suzuki H, Sawada M, Trapani G
    • Journal Title

      Pharmaceutical Research

      Volume: 28 Pages: 2820-2832

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of a brain-engraftable microglial cell line expressing anti-prion scFv antibodies on survival times of mice infected with scrapie prions2011

    • Author(s)
      Fujita K, Yamaguchi Y, Mori T, Muramatsu N, Miyamoto T, Yano M, Miyata H, Ootsuyama A, Sawada M, Matsuda H, Kaji R, Sakaguchi S
    • Journal Title

      Cellular and Molecular Neurobiology

      Volume: 31 Pages: 999-1008

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Matrix metallo- proteinase-9 contributes to kindled seizure development in pentylene- tetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus2011

    • Author(s)
      Mizoguchi H, Nakade J, Tachibana M, Ibi D, Someya E, Koike H, Kamei H, Nabeshima T, Itohara S, Takuma K, Sawada M, Sato J, Yamada K
    • Journal Title

      Journal of Neuroscience

      Volume: 31 Pages: 12963-12971

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 4-hydroxy- 2-nonenal upregulates and phosphorylates cytosolic phosphol- ipase A (2) in cultured Ra2 microglial cells via MAPK pathways2011

    • Author(s)
      Shibata N, Kato Y, Inose Y, Hiroi A, Yamamoto T, Morikawa S, Sawada M, Kobayashi M
    • Journal Title

      Neuropathology

      Volume: 31 Pages: 122-128

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 4-hydroxy-2-nonenal upregulates and phosphorylates cytosolic phospholipase A (2) in cultured Ra2 microglial cells via MAPK pathways2011

    • Author(s)
      Shibata N, Kato Y, Inose Y, Hiroi A, Yamamoto T, Morikawa S, Sawada M, Kobayashi M
    • Journal Title

      Neuropathology

      Volume: 31(2) Issue: 2 Pages: 122-128

    • DOI

      10.1111/j.1440-1789.2010.01139.x

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus2011

    • Author(s)
      H Mizoguchi, J Nakade, M Tachibana, D Ibi, E Someya, H Koike, H Kamei, T Nabeshima, S Itohara, K Takuma, M Sawada, J Sato, K Yamada
    • Journal Title

      Journal of Neuroscience

      Volume: 31 Issue: 36 Pages: 12963-12971

    • DOI

      10.1523/jneurosci.3118-11.2011

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of a brain-engraftable microglial cell line expressing anti-prion scFv antibodies on survival times of mice infected with scrapie prions2011

    • Author(s)
      Fujita K, Yamaguchi Y, Mori T, Muramatsu N, Miyamoto T, Yano M, Miyata H, Ootsuyama A, Sawada M, Matsuda H, Kaji R, Sakaguchi S
    • Journal Title

      Cell Mol Neurobiol

      Volume: 31(7) Issue: 7 Pages: 999-1008

    • DOI

      10.1007/s10571-011-9696-z

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] New fluorescent probes targeting the mitochondrial-located translocator protein 18 kDa (TSPO) as activated microglia imaging agents2011

    • Author(s)
      Denora N, Laquintana V, Trapani A, Suzuki H, Sawada M, Trapani G
    • Journal Title

      Pharm Res

      Volume: 28(11) Issue: 11 Pages: 2820-2832

    • DOI

      10.1007/s11095-011-0552-0

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 光操作によるミクログリアの活性化2013

    • Author(s)
      澤田 誠
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] ミクログリアのサブタイプ、毒性転換と脳機能発現との関わり2013

    • Author(s)
      澤田 誠
    • Organizer
      第29回Neuroscience Seminar Tokushima
    • Place of Presentation
      徳島
    • Related Report
      2012 Final Research Report
  • [Presentation] 光操作によるミクログリアの活性化2013

    • Author(s)
      澤田 誠
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船堀
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] チャネルロドプシン 2を導入したOS3 グリア前駆細胞株における細胞分化の光制御2012

    • Author(s)
      小野健治、山本龍生、佐橋秀紀、鈴木弘美、澤田 誠
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] Optogenetic control of cell differentiation in channelrhodopsin-2 expressing OS3, a bipotential glial progenitor cell line2012

    • Author(s)
      Ono K, Yamamoto R, Sahashi H, Suzuki H, Sawada M
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] ミクログリアのサブタイプと毒性転換について2012

    • Author(s)
      澤田 誠
    • Organizer
      Japanese Consortium for Age-related Neurodegenerative disorders
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 光機能制御グリア細胞を用いた神経修復・髄鞘再生戦略2012

    • Author(s)
      澤田 誠
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 血液脳関門を壊さない安全性の高い脳標的化技術2012

    • Author(s)
      澤田 誠
    • Organizer
      大学発・選り抜きバイオセミナー第13回
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒトはなぜ夢をみるのか?2012

    • Author(s)
      澤田 誠
    • Organizer
      名大カフェ"Science, and Me"
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] ミクログリアのサブタイプと毒性転換2012

    • Author(s)
      澤田 誠
    • Organizer
      愛知県心身障害者コロニー発達障害研究所公開セミナー
    • Place of Presentation
      春日井,愛知
    • Related Report
      2012 Final Research Report
  • [Presentation] 光機能制御グリア細胞を用いた神経修復・髄鞘再生戦略2012

    • Author(s)
      澤田 誠
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Optogenetic control of cell differentiation in channelrhodopsin-2 expressing OS3, a bipotential glial progenitor cell line2012

    • Author(s)
      Ono K, Yamamoto R, Sahashi H, Suzuki H, Sawada M
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] チャネルロドプシン2を導入したOS3グリア前駆細胞株における細胞分化の光制御2012

    • Author(s)
      小野健治、山本龍生、佐橋秀紀、鈴木弘美、澤田 誠
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] ミクログリアのサブタイプと毒性転換2012

    • Author(s)
      澤田 誠
    • Organizer
      愛知県心身障害者コロニー発達障害研究所公開セミナー(招待講演)
    • Place of Presentation
      愛知県心身障害者コロニー(春日井)
    • Related Report
      2011 Research-status Report
  • [Presentation] ヒトはなぜ夢をみるのか?2012

    • Author(s)
      澤田 誠
    • Organizer
      名大カフェ"Science, and Me"
    • Place of Presentation
      アルテーゴドゥショウズ(名古屋)
    • Related Report
      2011 Research-status Report
  • [Presentation] 血液脳関門を壊さない安全性の高い脳標的化技術2012

    • Author(s)
      澤田 誠
    • Organizer
      大学発・選り抜きバイオセミナー第13回
    • Place of Presentation
      バイオインダストリー協会(JBA)(東京)
    • Related Report
      2011 Research-status Report
  • [Presentation] 光を使ってミクログリアの毒性転換をコントロールする2011

    • Author(s)
      澤田 誠
    • Organizer
      第8回群馬大学名古屋大学合同シンポジウム
    • Place of Presentation
      前橋
    • Related Report
      2012 Final Research Report
  • [Presentation] 光を使ってミクログリアの毒性転換を調節する2011

    • Author(s)
      澤田 誠
    • Organizer
      第9回神経科学研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 神経疾患モデルにおけるミクログリアの毒性転換と脳機能の画像化の試み2011

    • Author(s)
      澤田 誠
    • Organizer
      アステラス製薬バイオイメージング研究所・薬理研究所合同セミナー
    • Place of Presentation
      筑波
    • Related Report
      2012 Final Research Report
  • [Presentation] Visualization of iNOS gene expression from activated cells in magnetic resonance imaging[[10122]]2011

    • Author(s)
      Ono K, Tabata K, Suzuki H, Sawada M
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] ミクログリアの毒性転換のイメージングとサブタイプ2011

    • Author(s)
      澤田 誠
    • Organizer
      ミクログリア研究会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] 細胞を使った脳の標的化技術と脳の機能イメージング2011

    • Author(s)
      澤田 誠
    • Organizer
      第19回薬理学セミナー
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] ミクログリアの毒性転換のイメージングとサブタイプ2011

    • Author(s)
      澤田 誠
    • Organizer
      ミクログリア研究会(招待講演)
    • Place of Presentation
      アスビオファーマ本社(神戸)
    • Related Report
      2011 Research-status Report
  • [Presentation] 神経疾患モデルにおけるミクログリアの毒性転換と脳機能の画像化の試み2011

    • Author(s)
      澤田 誠
    • Organizer
      アステラス製薬バイオイメージング研究所・薬理研究所合同セミナー(招待講演)
    • Place of Presentation
      アステラス製薬バイオイメージング研究所(筑波)
    • Related Report
      2011 Research-status Report
  • [Presentation] 光を使ってミクログリアの毒性転換を調節する2011

    • Author(s)
      澤田 誠
    • Organizer
      第9回神経科学研究会(招待講演)
    • Place of Presentation
      大日本住友製薬東京支社(東京)
    • Related Report
      2011 Research-status Report
  • [Presentation] Visualization of iNOS gene expression from activated cells in magnetic resonance imaging[[10122]]2011

    • Author(s)
      Ono K, Tabata K, Suzuki H Sawada M
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2011 Research-status Report
  • [Presentation] 細胞を使った脳の標的化技術と脳の機能イメージング2011

    • Author(s)
      澤田 誠
    • Organizer
      第19回薬理学セミナー
    • Place of Presentation
      愛知学院大学(名古屋)
    • Related Report
      2011 Research-status Report
  • [Presentation] 光を使ってミクログリアの毒性転換をコントロールする2011

    • Author(s)
      澤田 誠
    • Organizer
      第8回群馬大学名古屋大学合同シンポジウム
    • Place of Presentation
      群馬大学・生体調節研究所(前橋)
    • Related Report
      2011 Research-status Report
  • [Presentation] ミクログリアのサブタイプと毒性転換について

    • Author(s)
      澤田 誠
    • Organizer
      Japanese Consortium for Age-related Neurodegenerative disorders
    • Place of Presentation
      ベルサール八重洲
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ミクログリアのサブタイプ、毒性転換と脳機能発現との関わり

    • Author(s)
      澤田 誠
    • Organizer
      第29回Neuroscience Seminar Tokushima
    • Place of Presentation
      徳島大学病院 日亜メディカルホール
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] なぜひとは夢をみるのか?子供の科学2012

    • Author(s)
      澤田 誠
    • Total Pages
      10
    • Publisher
      誠文堂新光社
    • Related Report
      2012 Final Research Report
  • [Book] なぜ人は夢をみるのか? 子供の科学2012

    • Author(s)
      澤田 誠
    • Publisher
      誠文堂新光社
    • Related Report
      2011 Research-status Report
  • [Book] てんかんとアストロサイト CLINICAL NEUROSCIENCE2011

    • Author(s)
      澤田 誠
    • Publisher
      中外医学社
    • Related Report
      2012 Final Research Report
  • [Book] ミクログリアによる BBB 非崩壊型の脳へのターゲティング DDS2011

    • Author(s)
      澤田 誠、鈴木弘美、小野健治
    • Publisher
      日本薬剤学会
    • Related Report
      2012 Final Research Report
  • [Book] Role of microglia in inflammatory process in Parkinson's disease. Etiology and Pathophysiology of Parkinson's Disease2011

    • Author(s)
      Sawada H, Suzuki H, Ono K, Imamura K, Nagatsu T, Sawada M
    • Publisher
      Walters Kluwer
    • Related Report
      2012 Final Research Report
  • [Book] てんかんとアストロサイト CLINICAL NEUROSCIENCE2011

    • Author(s)
      澤田 誠
    • Publisher
      中外医学社
    • Related Report
      2011 Research-status Report
  • [Book] ミクログリアによるBBB非崩壊型の脳へのターゲティングDDS 薬剤学2011

    • Author(s)
      澤田 誠、鈴木弘美、小野健治
    • Publisher
      日本薬剤学会
    • Related Report
      2011 Research-status Report
  • [Book] Role of microglia in inflammatory process, in Parkinso’s disease. Etiology and Pathophysiology of Parkinson’s Disease2011

    • Author(s)
      Sawada H, Suzuki H, Ono K, Imamura K, Nagatsu T, Sawada M
    • Publisher
      Walters Kluwer Health
    • Related Report
      2011 Research-status Report
  • [Patent(Industrial Property Rights)] 蛍光プローブ及びその製造方法2012

    • Inventor(s)
      小野健治、澤田誠、渕真吾、竹田美和
    • Industrial Property Rights Holder
      国立大学法人名古屋大学
    • Filing Date
      2012-07-17
    • Related Report
      2012 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 蛍光プローブ及びその製造方法2012

    • Inventor(s)
      小野健治、澤田誠、渕真吾、竹田美和
    • Industrial Property Rights Holder
      国立大学法人 名古屋大学(現在 出願人)
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-07-17
    • Related Report
      2012 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 蛍光プローブ及びその製造方法2011

    • Inventor(s)
      小野健治、澤田誠、渕真吾、竹田美和
    • Industrial Property Rights Holder
      国立大学法人名古屋大学
    • Industrial Property Number
      2011-160261
    • Filing Date
      2011-07-21
    • Related Report
      2012 Final Research Report 2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi