Research Project
Grant-in-Aid for Challenging Exploratory Research
We previously identified a novel mitochondrial ubiquitin ligase called MITOL. MITOL has been shown to control mitochondrial dynamics by regulating mitochondrial fission factors such as Drp1 (EMBO J 2006). In this research project, we found that MITOL protects neuronal cells from mitochondrial damage caused by accumulation of MAP1B-light chain 1 (PNAS 2012). Therefore, MITOL is involved in mitochondrial dynamics, mitochondrial quality control, and protection against oxidative stress. Most recently, we foundthat MITOL regulates E R-mitochondria interaction by controlling Mfn2 activity (Mol Cell 2013). These results suggest that MITOL plays a critical role in mitochondrial regulation and oxidative signaling. Further investigations may shed light on new protective role of MITOL against oxidative stresses
All 2013 2012 2011 Other
All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (27 results) (of which Invited: 3 results)
Mol. Cell
Volume: 51 Issue: 1 Pages: 1-15
10.1016/j.molcel.2013.04.023
Volume: in press
Proc. Natl. Acad. Sci. U.S.A.
Volume: 109(7) Issue: 7 Pages: 2382-2387
10.1073/pnas.1114985109
J. Biol. Chem
Volume: 286(39) Issue: 39 Pages: 33879-33889
10.1074/jbc.m111.234997
PLoS One
Volume: 6(電子媒体による発表) Issue: 8 Pages: e23324-e23324
10.1371/journal.pone.0023324
