Functional analysis of neuronal circuit by synaptic photoinactivation
| Project/Area Number |
23650201
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Hokkaido University |
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Principal Investigator |
KAMIYA Haruyuki 北海道大学, 大学院・医学研究科, 教授 (10194979)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 海馬 / シナプス / グルタミン酸受容体 / 光操作 / 脳・神経 / 神経科学 / 生理学 / 薬理学 / シグナル伝達 |
|---|
| Research Abstract |
To clarify the roles of individual input in the complex neuronal circuitry, photochemical inactivation of glutamatergic transmission using a photoreactive AMPA receptor antagonist ANQX was adopted for hippocampal slice preparations. Input (layer) specific block was applicable to the hippocampal slice preparation using local UV illumination in combination with application of ANQX.
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Report
(3 results)
Research Products
(15 results)
