Reconstruction of gait capability of cerebellar ataxia using neuro-engineering procedures
Project/Area Number |
23650202
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Neurophysiology and muscle physiology
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Research Institution | Asahikawa Medical College |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
OTA Jun 東京大学, 人工物工学研究センター, 教授 (50233127)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 小脳性歩行失調 / 姿勢筋緊張 / 網様体脊髄路 / 機能再建 / 除脳動物 / 機能的電気刺激 / 脳深部刺激 / ブレインマシンインターフェイス / 脳深部刺激法 |
Research Abstract |
This is a basic study aiming at reconstructing gait ataxia of cerebellar damaged animals using neuro-engineering procedures. For this purpose, here we elucidated locomotor ataxia of animals following damages of various areas of the cerebellum. Rats with damages of medial cerebellum displayed hypotonia with severe postural instability and locomotor ataxia. Although such locomotor deficits were not prominent in the rats with damages of lateral cerebellum, they became hypokinetsia when they encountered unfamiliar circumstances. By removal of the whole cerebellum, spontaneous movements were mostly disappeared and the rats became akinesia. These results suggest that the cerebellum plays crucial roles in initiation of locomotor behaviors, and the medial and the lateral part may contribute to posture-locomotor synergies and to locomotor adaptation, respectively. Different neuro-engineering procedures will be required to reconstructing gait ataxia with damages of medial and lateral cerebellum.
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Report
(4 results)
Research Products
(161 results)
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[Presentation] 脳幹網様体の機能2013
Author(s)
高草木薫
Organizer
日本ボバース研究会・関東甲信越ブロック研修会
Place of Presentation
東京
Year and Date
2013-02-09
Related Report
Invited
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[Presentation] 身体性システム科学の構築を目指して2013
Author(s)
太田順,今水寛,関和彦,淺間一,出江紳一,芳賀信彦,近藤敏行,内藤栄一,村田哲,花川隆,高草木薫,稲巴哲也
Organizer
継続自動制御学会システム・情報部門学術講演会
Place of Presentation
大津
Related Report
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