Structure-function analyses of inhibitory terminals in midbrain nucleus substantia nigra
| Project/Area Number |
23650203
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Hirosaki University |
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Principal Investigator |
YAMADA Katsuya 弘前大学, 大学院・医学研究科, 准教授 (40241666)
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| Co-Investigator(Renkei-kenkyūsha) |
NAGATOMO Katsuhiro 弘前大学, 大学院・医学研究科, 研究員 (30542568)
YAMAMOTO Yoshio 岩手大学, 農学部, 教授 (10252123)
SUGA Sechiko 弘前医療福祉大学, 保健学部, 教授 (80003408)
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| Project Period (FY) |
2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | ニューロン / シナプス / 神経回路 |
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| Research Abstract |
It is a matter of debate whether the gap junction (GJ), a pathway for ions and small molecules between adjacent cells, exists between axon terminals in the adult brain. To approach the final goal demonstrating such GJs by patch clamping from adjacent axon terminals, the present study was designed as the first step. Three dimensional live images of a pair of adjacent GABAergic axon terminals, situated on a neuron side-by-side, were successfully obtained using a real time laser confocal microscopy. Some critical techniques were established in the present study towards the goal.
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Report
(2 results)
Research Products
(20 results)
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[Journal Article] Syntheses of 2-NBDG analogues for monitoring stereoselective uptake of D-glucose2011
Author(s)
Yamamoto, T., Tanaka, S., Suga. S., Watanabe. S., Nagatomo, K., Sasaki, A., Nishiuchi, Y., Teshima, T., and Yamada, K
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Journal Title
Bioorg. Med. Chem. Lett
Volume: 21巻
Issue: 13
Pages: 4088-4096
DOI
Related Report
Peer Reviewed
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[Book] 生化学辞典
Author(s)
山田勝也
Publisher
(株)朝倉書店(in press)
Related Report
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