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Comprehensive analysis of in vivo substrates of protein kinase C

Research Project

Project/Area Number 23650214
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Fusional basic brain science
Research InstitutionThe University of Tokyo

Principal Investigator

AIBA Atsu  東京大学, 大学院・医学系研究科, 教授 (20271116)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords脳分子プロファイリング / 遺伝子操作マウス / プロテインキナーゼC / プロテオミクス
Research Abstract

Protein kinase C (PKC) γ is involved in cerebellar functions such as motor coordination and elimination of climbing fiber-Purkinje cell synapses. Molecular mechanisms of PKCγ-regulating cerebellar processes are elusive, due to the heretofore undescribed in vivo substrates of PKCγ. In this study, a series of candidate molecules for PKCγ substrates in mouse cerebellum was identifiedby quantitative phospho-proteomic analysis.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (15 results)

All 2013 2012 2011 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (4 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin2013

    • Author(s)
      Asahara S
    • Journal Title

      Diabetologia

      Volume: なし Issue: 5 Pages: 1088-1097

    • DOI

      10.1007/s00125-013-2849-5

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Guidepost neurons for the lateral olfactory tract : expression of metabotropic glutamate receptor 1 and linnervation by glutamatergic olfactory bulb axons2012

    • Author(s)
      Hirata, T., Kumada, T., Kawasaki, T., Furukawa, T., Aiba, A., Conquet, F., Saga, Y. and Fukuda, A.
    • Journal Title

      Dev. Neurobiol

      Volume: (in press) Issue: 12 Pages: 1559-1576

    • DOI

      10.1002/dneu.22030

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional coupling of the metabotropic glutamate receptor, InsP3 receptor and L-type Ca2+ channel in mouseCA1 pyramidal cells.2012

    • Author(s)
      Kato HK, Kassai H, Watabe AM, Aiba A, Manabe T
    • Journal Title

      Journal of Physiology

      Volume: 590 Issue: 13 Pages: 3019-3034

    • DOI

      10.1113/jphysiol.2012.232942

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling2012

    • Author(s)
      Nishimura S, Manabe I, Nagasaki M, Kakuta S, Iwakura Y, Takayama N, Ooehara J, Otsu M, Kamiya A, Petrich BG, Urano T, Kadono T,Sato S, Aiba A, Yamashita H, Sugiura S, Kadowaki T, Nakauchi H, Eto K, Nagai R
    • Journal Title

      Blood

      Volume: 119

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development2011

    • Author(s)
      Aizawa R, Yamada A, Suzuki D, Iimura T, Kassai H, Harada T, Tsukasaki M, Yamamoto G, Tachikawa T, Nakao K, Yamamoto M, Yamagchi A, Aiba A, Kamijo R
    • Journal Title

      AMech Dev

      Volume: (In press) Issue: 1-4 Pages: 38-50

    • DOI

      10.1016/j.mod.2012.02.002

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Suppression of a neocortical potassium channel activity by intracellular amyloid-ss and its rescue with Homer1a2011

    • Author(s)
      Yamamoto K, Ueta Y, Wang L, Yamamoto R, Inoue N, Inokuchi K, Aiba A, Yonekura H, Kato N
    • Journal Title

      Journal of Neuroscience

      Volume: 31 Pages: 11100-11109

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling2011

    • Author(s)
      S.Nishimura
    • Journal Title

      Blood

      Volume: 119 Issue: 8 Pages: 128-131

    • DOI

      10.1182/blood-2011-09-381400

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Suppression of a neocortical potassium channel activity by intracellular amyloid-β and its rescue with Homer1a.2011

    • Author(s)
      Yamamoto K, Ueta Y, Wang L, Yamamoto R, Inoue N, Inokuchi K, Aiba A, Yonekura H, Kato N.
    • Journal Title

      Journal of Neuroscience

      Volume: 31 Issue: 31 Pages: 11100-11109

    • DOI

      10.1523/jneurosci.6752-10.2011

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 中枢神経系において恒常的活性化型mTORを発現するマウスの作製と解析2012

    • Author(s)
      饗場篤
    • Organizer
      日本分子生物学会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2012-12-13
    • Related Report
      2012 Final Research Report
  • [Presentation] 中枢神経系において恒常的活性化型mTORを発現するマウスの作製と解析2012

    • Author(s)
      饗場 篤
    • Organizer
      日本分子生物学会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Genetic dissection of mGluR1 function in cerebellar Purkinje cells2011

    • Author(s)
      Aiba A
    • Organizer
      7th International Meeting on Metabotropic Glutamate Receptors
    • Place of Presentation
      Grande Albergo Capotaormina (Italy)
    • Year and Date
      2011-10-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Genetic dissection of mGluR1 function in cerebellar Purkinje cells2011

    • Author(s)
      Aiba, A
    • Organizer
      7th International Meeting on Metabotropic Glutamate Receptors(招待講演)
    • Place of Presentation
      Capotaormina (Italy)
    • Related Report
      2011 Research-status Report
  • [Book] 「mTORシグナルによる脳機能の調節と破綻」細胞工学2012

    • Author(s)
      葛西秀俊,饗場篤
    • Publisher
      学研メディカル秀潤社
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://lar.cdbim.m.u-tokyo.ac.jp/

    • Related Report
      2012 Final Research Report
  • [Remarks] 東京大学大学院医学系研究科疾患生命工学センター動物資源学部門ホームページ

    • URL

      http://lar.cdbim.m.u-tokyo.ac.jp/index.html

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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