Functional analysis of DNA methylation in post-mitotic neurons
| Project/Area Number |
23650215
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Fusional basic brain science
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
NAMIHIRA Masakazu 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (60379534)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ニューロン / 発達 / DNA メチル化 / エピジェネティクス / DNA ヒドロキシメチル化 / DNAメチル化 / DNAヒドロキシメチル化 |
|---|
| Research Abstract |
Although neurons are postmitotic cells, which completely have exited cell cycle, the expression of DNA methyltransferase 1 (DNMT1) is observed in the cells. However, the function of DNMT1 in postmitotic neurons is unclear. To address this issue, we deleted Dnmt1 gene in neurons and examined the resultant phenotype in vitro.We found that DNMT1 plays an important role in cortical development through the regulation of neurite outgrowth mediated by neurotrophic factor signaling
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Report
(3 results)
Research Products
(34 results)
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[Journal Article] Treatment of a mouse model of spinal cord injury by transplantation of human iPS cell-derived long-term self-renewing neuroepithelial-like stem cells2012
Author(s)
Fujimoto Y., Abematsu M., FalkA., Tsujimura K., Sanosaka T., Juliandi B.. Semi K., Namihira M., Komiya S., SmithA., Nakashima K,
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Journal Title
Stem Cells
Volume: 30
Issue: 6
Pages: 1163-1173
DOI
Related Report
Peer Reviewed
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[Presentation] Treatment of a mouse model of spinal cord injury by transplantation of human iPS cell-derived long term self-renewing neuroepithelial-like stem cells2012
Author(s)
Fujimoto, Y., Abematsu, M., Falk, A., Tsujimura,K., Sanosaka, T., Juliandi, B., Semi, K., Namihira,M., Komiya, S., Smith, A., Nakashima, K.
Organizer
NEUROSCIENCE 2012
Place of Presentation
New Orleans
Year and Date
2012-10-15
Related Report
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[Presentation] TLR9-signaling regulates neurogenesis in the adult mouse hippocampus2012
Author(s)
Matsuda, T., Murao, N., Juliandi, B.,Namihira, M., Kawai, T., Akira, S.,Nakashima, K.
Organizer
NEUROSCIENCE 2012
Place of Presentation
New Orleans
Year and Date
2012-10-13
Related Report
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[Presentation] DNMT1 regulates neuronal differentiation of neural precursor cell in late-gestational forebrain.2012
Author(s)
Noguchi, H., Namihira, M., Tanaka, T., Sanosaka, T., Nakashima, K.
Organizer
40th KEYSTONE SYMPOSIA
Place of Presentation
Keystone, Colorado, USA
Related Report
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[Presentation] Treatment of a mouse model of spinal cord injury by transplantation of human iPS cell-derived long-term self-renewing neuroepithelial-like stem cells
Author(s)
Fujimoto, Y., Abematsu, M., Falk, A., Tsujimura, K., Sanosaka, T., Juliandi, B., Semi, K., Namihira, M., Komiya, S., Smith, A., Nakashima, K.
Organizer
NEUROSCIENCE 2012
Place of Presentation
New Orleans
Related Report
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[Presentation] TLR9-signaling regulates neurogenesis in the adult mouse hippocampus.
Author(s)
Matsuda, T., Murao, N., Juliandi, B., Namihira, M., Kawai, T., Akira, S., Nakashima, K.
Organizer
NEUROSCIENCE 2012
Place of Presentation
New Orleans
Related Report
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