| Project/Area Number |
23650228
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory animal science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | E G FP / パルボウイルス / 発癌 / ＥＧＦＰ / 発がん / EGFP |
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| Research Abstract |
The present study is aimed to develop the transgenic mouse that express reporter gene, EGFP, under the parvovirus P4 promoter, and to visualize tumor by in vivo imaging. The P4-EGFP Tg mice older than 20-days old expressed EGFP in spermatocytes of testis, but not in other tissues. Some of tumor tissues in P4-EGFP mice induced with carcinogen or mating to oncogenic ras H2 Tg mice, were detectable by EGFP expression.
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