Production of new design mice by accumulation of mutations
| Project/Area Number |
23650234
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory animal science
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| Research Institution | Osaka University |
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Principal Investigator |
YAGI Takeshi 大阪大学, 生命機能研究科, 教授 (10241241)
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| Co-Investigator(Renkei-kenkyūsha) |
UCHIMURA Arikuni 大阪大学, 生命機能研究科, 特任助教 (20513063)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 疾患モデル / 進化 / 突然変異 / マウス / 量的形質 / ゲノム / 表現型 / がん / エピスタシス |
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| Research Abstract |
To create new model to investigate mutational network controlling quantitative traits in vivo, we established several mutation accumulation (MA) lines with long term breeding of mutator mice. We observed differences in quantitative traits (weight, body length, tail length) between and within each of MA line. Biochemical analysis revealed MA lines include mice having dysfunctions of liver or kidney or arteriosclerosis. NGS analysis showed abundant de novo mutation in MA lines. Our approach using the MA lines would provide a new way to understand quantitative genetics in mammalian model.
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Report
(3 results)
Research Products
(32 results)
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[Journal Article] The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs.2012
Author(s)
Yamamoto M, Matsuzaki T, Takahashi R, Adachi E, Maeda Y, Yamaguchi S, Kitayama H, Echizenya M, Morioka Y, Alexander DB,Yagi T, Itohara S, Nakamura T, Akiyama H, and Noda M
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Journal Title
Biology Open
Volume: in press
Related Report
Peer Reviewed
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