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Development of a model mouse line for hair graying

Research Project

Project/Area Number 23650241
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Laboratory animal science
Research InstitutionNagoya University (2012-2014)
Chubu University (2011)

Principal Investigator

MASASHI Kato  名古屋大学, 医学(系)研究科(研究院), 教授 (10281073)

Co-Investigator(Kenkyū-buntansha) TAKEDA Kozue  中部大学, 生命健康科学部, 准教授 (80345884)
GOTO Yuji  中部大学, 生命健康科学部, 助手 (70362522)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsモデル動物 / 遺伝子改変マウス / 白髪 / メラノサイト / 国際情報交換 / モデルマウス / 加齢 / 発症機構 / 加齢性白髪 / フランス / シンガポール / ドイツ / アメリカ / 疾患モデル動物
Outline of Final Research Achievements

Hair graying is an ordinary disorder for hair pigmentation and a symbol for aging. At present, mechanism of hair graying remains largely unknown, whereas reports for genetically modified mice with changing levels of hair pigmentation are increasing in international scientific journals, according to the recent progression of molecular biology. However, there is very limited report showing model mouse lines for hair graying with aging. We developed original mouse lines for hair graying with aging. In this study, we clarify pathogenesis and molecular mechanism of hair graying in the mice. We also provide the evidence that the mice could be appropriate model mice for hair graying with aging. Moreover, we challenge to develop molecular target therapy for anti-hair graying.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (52 results)

All 2014 2013 2012 2011 Other

All Journal Article (33 results) (of which Peer Reviewed: 33 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (11 results) (of which Invited: 2 results) Remarks (5 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Effects of non-thermal atmospheric pressure plasma irradiation on expression levels of matrix metalloproteinases in benign melanocytic tumors in RET-transgenic mice.2014

    • Author(s)
      Iida M,Yajima I, Ohgami N, Tamura H, Takeda K, Ichihara S, Hori M, Kato M.
    • Journal Title

      Eur J Dermatol

      Volume: 24 Issue: 3 Pages: 392-394

    • DOI

      10.1684/ejd.2014.2330

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Non-equilibrium atmospheric pressure plasmas modulate cell cycle-related gene expressions in melanocytic tumors of RET-transgenic mice.2014

    • Author(s)
      Yajima I, Iida M, Kumasaka MY, Omata Y, Ohgami N, Chang J, Ichihara S, Hori M, Kato M.
    • Journal Title

      Exp Dermatol

      Volume: 23 Issue: 6 Pages: 424-425

    • DOI

      10.1111/exd.12415

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] An actin-binding protein Espin is a novel growth regulator for melanoma.2014

    • Author(s)
      Yanagishita T, Yajima I, Kumasaka MY, Iida M, Xiang L, Tamada Y, Mtsuoto Y, Watabnabe D, Kato M.
    • Journal Title

      J Invest Dermatol

      Volume: 134 Issue: 12 Pages: 2996-2999

    • DOI

      10.1038/jid.2014.249

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Non-thermal atmospheric pressure plasmas as a novel candidate for preventive therapy of melanoma.2014

    • Author(s)
      Omata Y, Iida M, Yajima I, Takeda K, Ohgami N, Masaru Hori H, Kato M.
    • Journal Title

      Environ Health Prev Med.

      Volume: 19 Issue: 5 Pages: 367-369

    • DOI

      10.1007/s12199-014-0399-1

    • NAID

      50009312844

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Melanoma-Initiating Cells Exploit M2 Macrophage TGF.2014

    • Author(s)
      Tham M, Tan KW, Keeble J, Wang X, Hubert S, Barron L, Tan NS, Kato M, Prevost-Blondel A, Angeli V, Abastado J-P.
    • Journal Title

      Oncotarget

      Volume: 5 Pages: 12027-12042

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] GNG2 inhibits invasion of human malignant melanoma cells with decreased FAK activity.2014

    • Author(s)
      Yajima I, Kumasaka MY, Yamanoshita O, Zou C, Li X, Ohgami N, Kato M.
    • Journal Title

      Am J Cancer Res

      Volume: 4 Pages: 182-188

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] T-cell mediated immune responses induced in ret transgenic mouse model of malignant melanoma.2013

    • Author(s)
      Abschuetz O, Osen W, Frank K, Kato M, Schadendorf D, Umansky V.
    • Journal Title

      Cancers

      Volume: 4 Issue: 2 Pages: 490-503

    • DOI

      10.3390/cancers4020490

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anti-tumor Effect of Paclitaxel is Mediated by Inhibition of MDSCs and Chronic Inflammation in the Spontaneous Melanoma Model.2013

    • Author(s)
      Sevko A, Sade-Feldman M, Kanterman J, Michels T, Falk C, Ramacher M, Kato M, Schadendorf D, Baniyash M, Umansky V.
    • Journal Title

      J Invest Dermatol

      Volume: in press Issue: 6 Pages: 1610-1619

    • DOI

      10.1038/jid.2012.444

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anti-tumor Effect of Paclitaxel is Mediated by Inhibition of MDSCs and Chronic Inflammation in the Spontaneous Melanoma Model.2013

    • Author(s)
      Sevko A, Michels T, Vrohlings M, Umansky L, Beckhove P, Kato M, Shurin GV, Shurin MR, Umansky V.
    • Journal Title

      J Immunol

      Volume: 190 Issue: 5 Pages: 2464-2471

    • DOI

      10.4049/jimmunol.1202781

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inflammatory monocytes are potent anti-tumor effectors controlled by regulatory CD4+ T cells.2013

    • Author(s)
      Pommier A, Delpoux A, Audemard A, Martin B, Douguet L, Lengagne R, Campion AL, Kato M, Avril MF, Auffray C, Lucas B, Prevost-Blondel A.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 110 Issue: 32 Pages: 13085-13090

    • DOI

      10.1073/pnas.1300314110

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Actin-binding Protein, Espin : a Novel Metastatic Regulator for Melanoma.2013

    • Author(s)
      Yanagishita T, Yajima I, Kumasaka MY, Kawamoto Y, Tsuzuki T, Matsumoto Y, Watanabe D and Kato M.
    • Journal Title

      Molecular Cancer Research

      Volume: 12 Issue: 3 Pages: 1-7

    • DOI

      10.1158/1541-7786.mcr-13-0468-t

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] T-cell mediated immune responses induced in ret transgenic mouse model of malignant melanoma.2013

    • Author(s)
      Abschuetz O, Osen W, Frank K, Kato M, Schadendorf D, Umansky V.
    • Journal Title

      Cancers

      Volume: in press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and Therapy.2012

    • Author(s)
      Ya manoshita O Kato M
    • Journal Title

      Dermatol Res Pract.

      Volume: 2012 Pages: 354191-354191

    • DOI

      10.1155/2012/354191

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reduced GNG2 expression levels in mouse malignant melanomas and human melanoma cell lines.2012

    • Author(s)
      Yajima I, Kumasaka YM, Naito Y, Yoshikawa T, Takahashi H, Funasaka Y, Suzuki T,Kato M
    • Journal Title

      Am J Cancer Res

      Volume: 2 Pages: 322-329

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cancer-induced immunosuppression: IL-18-elicited immunoablative NK cells2012

    • Author(s)
      Terme M, Ullrich E, Aymeric L, Meinhardt K, Coudert J, Desbois M, Ghiringhelli F, Viaud S, Ryffel B, Yagita H, Chen L, Mecheri S, Kaplanski G, Prevost-Blondel A, Kato M, Schultze JL, Tartour E, Kroemer G, Degli-Esposti M, Chaput N, Zitvogel L
    • Journal Title

      Cancer Res

      Volume: 72 Issue: 11 Pages: 2757-2767

    • DOI

      10.1158/0008-5472.can-11-3379

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tumor-Expressed Inducible Nitric Oxide Synthase Controls Induction of Functional Myeloid-Derived2012

    • Author(s)
      Jayaraman P, Parikh F, Lopez-Rivera E, Hailemichael Y, Clark A, Ma G, Cannan D, Ramacher M, Kato M, Overwijk WW, Chen SH, Umansky VY, Sikora AG.
    • Journal Title

      J Immunol

      Volume: 188 Issue: 11 Pages: 5365-5376

    • DOI

      10.4049/jimmunol.1103553

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Functional analysis of GNG2 in human malignant melanoma cells.2012

    • Author(s)
      Yajima I, et al.
    • Journal Title

      J Dermatol Sci.

      Volume: 68 Issue: 3 Pages: 172-178

    • DOI

      10.1016/j.jdermsci.2012.09.009

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] c-Ret-mediated hearing losses.2012

    • Author(s)
      Ohgami, N., Kato, M(10人中10番目), et al.
    • Journal Title

      Int J Clin Exp Pathol.

      Volume: 5 Pages: 23-8

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Partial impairment of c-Ret at tyrosine 1062 accelerates age-related hearing loss in mice2012

    • Author(s)
      Nobutaka Ohgami
    • Journal Title

      Neurobiol Aging

      Volume: 33 Issue: 3 Pages: 626.e25-626.e34

    • DOI

      10.1016/j.neurobiolaging.2011.04.002

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Barium Promotes Anchorage-Independent Growth and Invasion of Human HaCaT Keratinocytes via Activation of c-SRC Kinase2011

    • Author(s)
      Thang ND
    • Journal Title

      PLoS One

      Volume: 10 Issue: 3 Pages: 207-212

    • DOI

      10.1016/j.jdermsci.2011.10.010

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] L-cysteine as a regulator for arsenic-mediated cancer-promoting and anti-cancer effects2011

    • Author(s)
      Kato M, Kumasaka MY, Takeda K, Hossain K, Iida M, et al
    • Journal Title

      Toxicol In Vitro, Elsevier

      Volume: 25(3) Issue: 3 Pages: 623-629

    • DOI

      10.1016/j.tiv.2010.12.012

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Control of Genetically Designed Protein Tyrosine Kinase Activities by Environment-Linked Redox Reactions.2011

    • Author(s)
      Nakashima, I., Kawamoto, Y., Takeda, K., Kato, M.
    • Journal Title

      Enzyme Res

      Volume: 10 Pages: 896567-896567

    • DOI

      10.4061/2011/896567

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Altered lipid profiles in the stratum corneum of Sjogren-Larsson syndrome.2011

    • Author(s)
      Nakajima K, Sano S, Uchida Y, Akiyama M, Morita Y, Shimizu H.
    • Journal Title

      J Dermatol Sci

      Volume: 63(1) Issue: 1 Pages: 64-6

    • DOI

      10.1016/j.jdermsci.2011.03.009

    • NAID

      10030891977

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Partial requirement of endothelin receptor B in spiral ganglion neurons for postnatal development of hearing2011

    • Author(s)
      Ida-Eto M, Ohgami N, Iida M, et al
    • Journal Title

      J Biol Chem, American Society for Biochemistry and Molecular Biology

      Volume: 286(34) Issue: 34 Pages: 29621-29626

    • DOI

      10.1074/jbc.m111.236802

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sunlight exposure-mediated DNA damage in young adults. Cancer Epidemiol Biomarkers Prev2011

    • Author(s)
      Kato M, Iida M, et al
    • Journal Title

      American Association for Cancer Research

      Volume: 20(8) Issue: 8 Pages: 1622-1628

    • DOI

      10.1158/1055-9965.epi-11-0228

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] IL-18 induces PD-1-dependent immunosuppression in cancer2011

    • Author(s)
      Terme M, Ullrich E, Aymeric L, Meinhardt K, Desbois M, Delahaye NF, Viaud S, Ryffel B, Yagita H, Kaplanski G, Prevost-Blondel A, Kato M, Schultze JL, Tartour E, Kroemer G, Chaput N, Zitvogel L
    • Journal Title

      Cancer Res

      Volume: 71 Issue: 16 Pages: 5412-5422

    • DOI

      10.1158/0008-5472.can-11-0993

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Proteomic identification of hippocampal proteins vulnerable to oxidative stress in excitotoxin-induced acute neuronal injury2011

    • Author(s)
      A. Furukawa, Y. Kawamoto, Y. Chiba, S.Takei, S. Hasegawa-Ishii, N. Kawamura, K. Yoshikawa, M. Hosokawa, S. Oikawa, M. Kato, A. Shimada
    • Journal Title

      Neurobiology of disease

      Volume: 43 Issue: 3 Pages: 706-714

    • DOI

      10.1016/j.nbd.2011.05.024

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Antioxidative effects of cherry leaves extract on tert-butyl hydroperocide-mediated cytotoxicity through regulation of thioredoxin-2 protein expression levels2011

    • Author(s)
      Taguchi N, Uemura N, Goto Y, Sakura M, Hara K, Niwa M, Iida M, Yanagishita T, Watanabe D, Kato M
    • Journal Title

      J Toxicol Environ Health A

      Volume: 74 Issue: 18 Pages: 1240-7

    • DOI

      10.1080/15287394.2011.570229

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor.2011

    • Author(s)
      Toh, B., Kato, M(10人中7番目), et al.
    • Journal Title

      PLoS Biol.

      Volume: 9 Issue: 9 Pages: e1001162-e1001162

    • DOI

      10.1371/journal.pbio.1001162

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Molecular Network Associated with MITF in Skin Melanoma Development and Progression.2011

    • Author(s)
      Ya manoshita O Kato M
    • Journal Title

      J Skin Cancer.

      Volume: 2011 Pages: 730170-730170

    • DOI

      10.1155/2011/730170

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sildenafil exerts anti-tumor effects and reduces Gr1+CD11b+ cell-mediated immunosuppression in ret transgenic mouse melanoma model.2011

    • Author(s)
      Meyer, C., Kato, M(8人中11番目), et al.
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 108 Issue: 41 Pages: 17111-6

    • DOI

      10.1073/pnas.1108121108

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Barium promotes anchorage-independent growth and invasion of human HaCaT keratinocytes via activation of c-SRC kinase.2011

    • Author(s)
      Thang, N.D., Kato, M(9人中9番目), et al.
    • Journal Title

      PLoS ONE

      Volume: 6 Issue: 10 Pages: e25636-e25636

    • DOI

      10.1371/journal.pone.0025636

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chemotherapy induces intratumoral expression of chemokines in cutaneous melanoma, favoring T cell infiltration and tumor control.2011

    • Author(s)
      Hong, M., Kato, M(11人中7番目), et al.
    • Journal Title

      Cancer Res.

      Volume: 71 Issue: 22 Pages: 6997-7009

    • DOI

      10.1158/0008-5472.can-11-1466

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Ednrb遺伝子関連メラノーマの予防、治療に有効な遺伝子の探索2014

    • Author(s)
      熊坂真由子、矢嶋伊知朗、飯田真知子、神保佳奈、田村青鳥、大神信孝、加藤昌志
    • Organizer
      第84回 日本衛生学会学術総会
    • Place of Presentation
      岡山県岡山市 岡山コンベンションセンター
    • Year and Date
      2014-05-25 – 2014-05-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 悪性黒色腫におけるNKX3-1遺伝子変異の解析2014

    • Author(s)
      山ノ下 理、玉利裕貴、加藤昌志
    • Organizer
      第84回 日本衛生学会学術総会
    • Place of Presentation
      岡山県岡山市 岡山コンベンションセンター
    • Year and Date
      2014-05-25 – 2014-05-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 悪性黒色腫におけるNKX3.1遺伝子変異の解析2013

    • Author(s)
      山ノ下理・岡澤泰平・加藤昌志
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢市 金沢大学鶴間・宝町キャンパス
    • Related Report
      2012 Research-status Report
  • [Presentation] 動物モデルを用いた非熱的大気圧プラズマによる抗腫瘍効果の検討2013

    • Author(s)
      飯田真智子、矢嶋伊知朗、中川薫、大神信孝、近藤 博基、竹田圭吾、堀勝、加納 浩之、加藤昌志
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢市 金沢大学鶴間・宝町キャンパス
    • Related Report
      2012 Research-status Report
  • [Presentation] Analysis of endothelin receptor B expressed in spiral ganglion neurons.2012

    • Author(s)
      大神信孝、飯田真智子、矢嶋伊知朗、加藤昌志
    • Organizer
      第24回日本色素細胞学会学術大会
    • Place of Presentation
      長浜市 長浜バイオ大学
    • Related Report
      2012 Research-status Report
  • [Presentation] 皮膚メラニンと日光曝露による酸化ストレスとの関連2012

    • Author(s)
      飯田真智子、矢嶋伊知朗、大神信孝、田巻満里絵、加藤昌志
    • Organizer
      第24回日本色素細胞学会学術大会
    • Place of Presentation
      長浜市 長浜バイオ大学
    • Related Report
      2012 Research-status Report
  • [Presentation] メラノーマにおけるGNG2の機能2012

    • Author(s)
      矢嶋伊知朗、熊坂真由子、大神信孝、加藤昌志
    • Organizer
      第24回日本色素細胞学会学術大会
    • Place of Presentation
      長浜市 長浜バイオ大学
    • Related Report
      2012 Research-status Report
  • [Presentation] Therapeutic effect of non-thermal atmospheric plasma on tumor in vivo2012

    • Author(s)
      Ichiro Yajima, Masashi Kato (7人中7番目)
    • Organizer
      4th International Symposium on Advanced Plasma Science and its Applications for Nitrides and Nanomaterials
    • Place of Presentation
      Chubu University, Kasugai, Aichi, Japan
    • Related Report
      2011 Research-status Report
  • [Presentation] A redox-linked novel pathway for2011

    • Author(s)
      Masashi Kato
    • Organizer
      JSPS AA Science Platform Program in Malaysia
    • Place of Presentation
      University Malaysia Sabah, Malaysia
    • Related Report
      2011 Research-status Report
  • [Presentation] メラニン制御を可能にする画期的なアンチエイジング剤の開発

    • Author(s)
      加藤昌志
    • Organizer
      第2回国際化粧品展
    • Place of Presentation
      東京ビックサイト(東京都江東区)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 環境を整え、病気を予防する:海外の環境衛生学研究を例として

    • Author(s)
      加藤昌志
    • Organizer
      豊秋奨学会国際学生交流会
    • Place of Presentation
      ホテル・ナゴヤキャッスル(名古屋市)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Remarks] 名古屋大学大学院医学系研究科・医学部医学科

    • URL

      http://www.med.nagoya-u.ac.jp/medical/2511/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 名古屋大学大学院医学系研究科 環境労働衛生学

    • URL

      http://www.med.nagoya-u.ac.jp/hygiene/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 名古屋大学大学院医学系研究科 教員詳細

    • URL

      http://profs.provost.nagoya-u.ac.jp/view/html/100001262_ja.html?k=%E5%8A%A0%E8%97%A4%E3%80%80%E6%98%8C%E5%BF%97

    • Related Report
      2013 Research-status Report
  • [Remarks] 名古屋大学大学院医学系研究科 環境労働衛生学

    • URL

      http://www.med.nagoya-u.ac.jp/hygiene/

    • Related Report
      2013 Research-status Report
  • [Remarks]

    • URL

      http://www.chubu.ac.jp/about/faculty/profile/588a920fe73a44df04e50c9c3eda630d04e09e86.html

    • Related Report
      2011 Research-status Report
  • [Patent(Industrial Property Rights)] 幹細胞を標的とした薬効及び毒性の評価法2013

    • Inventor(s)
      飯田真智子、加藤昌志
    • Industrial Property Rights Holder
      名古屋大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-131956
    • Filing Date
      2013-06-24
    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] 幹細胞を標的とした薬効及び毒性の評価法2012

    • Inventor(s)
      飯田真智子、加藤昌志
    • Industrial Property Rights Holder
      中部大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-243119
    • Filing Date
      2012-11-02
    • Related Report
      2012 Research-status Report
  • [Patent(Industrial Property Rights)] 色素細胞性疾患のモデル動物及びその用途2011

    • Inventor(s)
      加藤昌志、飯田真智子
    • Industrial Property Rights Holder
      中部大学
    • Industrial Property Number
      2011-253454
    • Filing Date
      2011
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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