| Project/Area Number |
23650243
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory animal science
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
KOIDE TSUYOSHI 国立遺伝学研究所, 系統生物研究センター, 准教授 (20221955)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI Aki 国立遺伝学研究所, 系統生物研究センター, 助教 (30581764)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 育種遺伝 / マウス / 攻撃性 / コンジェニック系統 / Ednrb / 毛色 / 野生マウス / 従順性 / マウス系統 / 愛玩化 / 遺伝子 |
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| Research Abstract |
Japanese fancy mouse strain JF1 shows black and white spots on their coat and exhibits highly obedient phenotype. In contrast, Japanese wild mouse derived strain MSM still exhibits wildness such as higher anxiety as well as high level of aggressive biting towards humans.
It has been reported that the spotting is caused by a mutation in Ednrb gene. Reduced expression of Ednrb gene resulted in aberrant growth/differentiation of melanocyte cells.
In order to examine a role of Ednrb on behaviors, we backcrossed the Ednrb mutation on MSM genetic background, and found that the mouse shows reduced anxiety-like behavior as well as lower level of aggression. The results showed that Ednrb gene has a role of regulating tameness in mice.
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