Mutual mapping of biomechanics models for comparative analysis of neuro-motor functions between human and mouse
| Project/Area Number |
23650246
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory animal science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
OOTA Satoshi 独立行政法人理化学研究所, バイオリソースセンター, 専任研究員 (30391890)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIKI Atsushi 独立行政法人理化学研究所, バイオリソースセンター, 室長 (40212310)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 神経筋骨格モデル / シミュレーション / 歩行 / 筋骨格モデル / 歩行パターン / 進化 / 遺伝子発現データ / 相同性 / ヒト / マウス / 生体力学 / セグメンテーション |
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| Outline of Final Research Achievements |
Based on anatomical landmarks, we mapped a topology of an existing human neuro-musculoskeletal model to a mouse skeletal model, and developed a prototype of the mouse neuro-musculoskeletal model. Using a gene expression pattern, we validated and adjusted the muscle origin and insertion sites of the model. We formalized the mapping method, and established a feasible method for the deformation. With the mouse model, we performed inverse kinematics and inverse dynamics for a mutant mouse. For an international collaboration to use results of this project, I participated an international workshop as an organizer. We developed a website of the workshop, through which we revealed our achievements.
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Report
(5 results)
Research Products
(9 results)
