Development of nano-template chip for immobilization and analysis of cartilaginous bio-polymer molecules
| Project/Area Number |
23650253
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Yamagata University |
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Principal Investigator |
MINETA Takashi 山形大学, 大学院・理工学研究科, 教授 (50374814)
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| Co-Investigator(Kenkyū-buntansha) |
KAKIZAKI Ikuko 弘前大学, 医学( 系) 研究科( 研究院), 准教授 (80302024)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | プロテオグリカン / 分子捕捉 / 基板表面処理 / ナノテンプレート / ヒアルロン酸 / ナノドット / ソフトスタンプ / 分子補足 |
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| Research Abstract |
Proteoglycan PG) and hyaluronic acid HAaggregate is an important bio-material for cartilaginous tissues. In order obtain perspective for HA-PG aggregate immobilization, this research focused on the development of a nano-dot-patterned surface modification with mono-molecular size for immobilize PG molecules. Surface modifications with nano-stamp translation technique and nano-lithographed patterning technique were attempt for the nano-dot patterned template chip. Moreover, trapping and resolving of HA molecular bundle between thin film nano-electrode couple was characterized in liquid.
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Report
(3 results)
Research Products
(18 results)
