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Mechanobiology of Cell Interaction using Optical Tweezers

Research Project

Project/Area Number 23650256
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biological material science
Research InstitutionNagoya University

Principal Investigator

MASUDA Taisuke  名古屋大学, 工学研究科, 特任助教 (30431513)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsバイオメカニクス / 力学刺激応答 / 細胞間相互作用
Research Abstract

A rapid construction process is necessary for building up numerous cell modules into three-dimensional (3D) tissues that retain the tissue geometries and initial conditions of the cells. We proposed a new 3D assembly technique using water transfer printing to fabricate a hollow tubular tissue structure. By utilizing this assembly technique, we discuss the relationship between the 3D transcriptional body of a gel matrix and the developed shape of transferred tissue, and then fabricate a hollow tubular tissue. Simulation of the 3D environment in which tissues normally develop and function is crucial for the engineering of in vitro models that can be used for the formation of complex tissues. These artificial hollow tubular tissues could be used as in vitro simulators for drug efficiency evaluation and operative training.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (14 results)

All 2013 2012 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (6 results) Remarks (2 results)

  • [Journal Article] Three-Dimensional Assembly of Multilayered Tissues2013

    • Author(s)
      Y. Yamagishi, T. Masuda, N. Takei
    • Journal Title

      Procedia CIRP

      Volume: 5 Pages: 201-204

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A microfabricated platform to form three-dimensional toroidal multicellular aggregate2012

    • Author(s)
      T. Masuda, N. Takei, T. Nakano
    • Journal Title

      Biomedical Microdevices

      Volume: 14 Pages: 1085-1093

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in stress distribution of orthodontic miniscrews and surrounding bone evaluated by 3-dimensional finite element analysis2011

    • Author(s)
      Suzuki A, Masuda T, Takahashi I, Deguchi T, Suzuki O, Takano-Yamamoto T
    • Journal Title

      Am J Orthod Dentofacial Orthop

      Volume: 140 Issue: 6 Pages: 273-280

    • DOI

      10.1016/j.ajodo.2011.06.025

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Effect of synthetic octacalcium phosphate in a collagen scaffold on the osteogenicity of mesenchymal stem cells2011

    • Author(s)
      T Kawai, T Anada, T Masuda, Y Honda, Y Sakai, Y Kato, S Kamakura, S Echigo, O Suzuki
    • Journal Title

      European Cells and Materials

      Volume: 22 Pages: 124-136

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] On-Chip Magnetically Actuated Robot with Ultrasonic Vibration for Single Cell Manipulations2011

    • Author(s)
      M.Hagiwara, T.Kawahara, Y.Yamanishi, T.Masuda, L.Feng, F.Arai
    • Journal Title

      Lab on a Chip

      Volume: 11 Issue: 12 Pages: 2049-2054

    • DOI

      10.1039/c1lc20164f

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Nanomanipilation of single influenza virus using dielectrophoretic concentration and optical tweezers for single virus infection to a specific cell on a microfluidic chip2011

    • Author(s)
      H Maruyama, K Kotani, T Masuda, A Honda, T Takahata, F Arai
    • Journal Title

      Microfluid Nanofluid

      Volume: 10 Issue: 5 Pages: 1109-1117

    • DOI

      10.1007/s10404-010-0739-4

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Rapid construction of multilayered tissues on curved substrate by water transfer printing2012

    • Author(s)
      T Masuda
    • Organizer
      The 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences
    • Place of Presentation
      Okinawa, Japan
    • Year and Date
      2012-11-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Rapid construction of multilayered tissues on curved substrate by water transfer printing2012

    • Author(s)
      Taisuke Masuda
    • Organizer
      The 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences (micro TAS)
    • Place of Presentation
      Okinawa
    • Related Report
      2012 Annual Research Report
  • [Presentation] バイオ MEMS を用いたマルチスケール細胞操作2011

    • Author(s)
      益田泰輔
    • Organizer
      第9回バイオレオロジーリサーチフォーラム(招待講演
    • Place of Presentation
      大阪府
    • Year and Date
      2011-06-02
    • Related Report
      2012 Final Research Report
  • [Presentation] バイオMEMSを用いたマルチスケール細胞操作2011

    • Author(s)
      益田泰輔
    • Organizer
      第9回バイオレオロジーリサーチフォーラム(招待講演)
    • Place of Presentation
      関西大学 100周年記念会館(大阪府)
    • Related Report
      2011 Research-status Report
  • [Presentation] Toroidal cellular aggregates for directed assembly of multicellular structure2011

    • Author(s)
      T Masuda, N Takei, T Nakano, F Arai
    • Organizer
      15th Internationl Conference on Miniaturized Systems for Chemistry and Life Sciences
    • Place of Presentation
      Seattle, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] Formation of toroidal multicellular aggregate of cardiomyocytes2011

    • Author(s)
      T Masuda, N Takei, T Nakano, F Arai
    • Organizer
      IEEE International Symposium on Micro-Nano Mechatronics and Human Science
    • Place of Presentation
      Nagoya, Japan
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.biorobotics.mech.nagoya-u.ac.jp/index.html

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.biorobotics.mech.nagoya-u.ac.jp/index.html

    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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