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Optical control of cell activity by introduction of photo-switching compound

Research Project

Project/Area Number 23650259
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biological material science
Research InstitutionDokkyo Medical University (2012-2013)
Kyoto University (2011)

Principal Investigator

MAGOME Nobuyuki  獨協医科大学, 医学部, 准教授 (70390052)

Co-Investigator(Kenkyū-buntansha) AGLADZE Konstantin  京都大学, 物質-細胞統合システム拠点, 教授 (30503651)
ORLOVA Yuliya  京都大学, 物質-細胞統合システム拠点, 研究員 (90571901)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords光スイッチング / 心筋細胞 / 興奮性 / 光制御 / ナノ粒子 / 細胞導入 / アゾ化合物 / HDL / 金ナノロッド / 紫外―可視
Research Abstract

In this research subject, we made nano-sized complex, consisting of lipid, protein, and photo-switching molecules, and then the complex were introduced into cultivated cardiomyocyte in order to realize optical control of excitation of the cells. We found that the complexes were easily taken into the cells, and also were disassembled within the cell. As a result, the photo-switching molecules diffuse inside the cell, and then interact with cell membrane. In the research process, it was observed that structure of cell membrane was reversibly modified by the photo-sensitive substance. According to this result, it is assumed that the change of structure causes to increase membrane permeability of ions and other substances.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (6 results)

All 2014 2013 2011

All Journal Article (6 results) (of which Peer Reviewed: 6 results)

  • [Journal Article] Multi-electrode monitoring of guided excitation in patterned cardiomyocytes2014

    • Author(s)
      L. Wang, L. Liu, X. Li, N. Magome, K. Agladze, and Y. Chen
    • Journal Title

      Micro-electron. Eng

      Volume: 111 Pages: 267-271

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multi-electrode monitoring of guided excitation in patterned cardiomyocytes2013

    • Author(s)
      L. Wang, L. Liu, X. Li, N. Magome, K. Agladze, and Y. Chen
    • Journal Title

      Microelectron Enginnering

      Volume: 111 Pages: 267-271

    • DOI

      10.1016/j.mee.2012.11.018

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Curvature-dependent excitation propagation in cultured cardiac tissue2011

    • Author(s)
      S. Kadota, M. W. Kay, N. Magome, and K. Agladze
    • Journal Title

      J. Exp. Theor. Phys. Lett

      Volume: 94 Pages: 838-844

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Digital photo-control of the network of live excitable cells2011

    • Author(s)
      I.S.Erofeev, N. Magome, and K. Agladze
    • Journal Title

      J. Exp. Theor. Phys. Lett

      Volume: 94 Pages: 513-516

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Photo-Control of Excitation Waves in Cardiomyocyte Tissue Culture2011

    • Author(s)
      N. Magome, G. Kanaporis, N. Moisan, K. Tanaka, and K. Agladze
    • Journal Title

      Tissue Engineering part A

      Volume: 17 Pages: 2703-2711

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Electronspun nanofibers as a tool for architecture control in engineered cardiac tissue2011

    • Author(s)
      Y. Orlova, N. Magome, L. Liu, Y. Chen, and K. Agladze
    • Journal Title

      Biomaterials

      Volume: 32 Pages: 5615-5624

    • Related Report
      2013 Final Research Report
    • Peer Reviewed

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Published: 2011-08-05   Modified: 2019-07-29  

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